Lipid/protein interactions and the membrane/water interfacial region.
Despite the importance of lipid/protein interactions in the folding, assembly, stability, and function of membrane proteins, information at an atomic level on how such proteins interact with the lipids that surround them remains sparse. The dynamics and flexible nature of the protein/bilayer interac...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1797069626037764096 |
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| author | Domene, C Bond, P Deol, S Sansom, MS |
| author_facet | Domene, C Bond, P Deol, S Sansom, MS |
| author_sort | Domene, C |
| collection | OXFORD |
| description | Despite the importance of lipid/protein interactions in the folding, assembly, stability, and function of membrane proteins, information at an atomic level on how such proteins interact with the lipids that surround them remains sparse. The dynamics and flexible nature of the protein/bilayer interaction make it difficult to study, for example, by crystallographic means. However, based on recent progress in molecular simulations of membranes it is possible to address this problem computationally. This communication reports one of the first attempts to use multiple ns molecular simulations to establish a qualitative picture of the intermolecular interactions between the lipids of a bilayer and two topologically different membrane proteins for which a high resolution (2 A or better) X-ray structure is available. |
| first_indexed | 2024-03-06T22:27:15Z |
| format | Journal article |
| id | oxford-uuid:5711576c-ed0a-4d23-9370-a0b9b8a65f84 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:27:15Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:5711576c-ed0a-4d23-9370-a0b9b8a65f842022-03-26T16:54:22ZLipid/protein interactions and the membrane/water interfacial region.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5711576c-ed0a-4d23-9370-a0b9b8a65f84EnglishSymplectic Elements at Oxford2003Domene, CBond, PDeol, SSansom, MSDespite the importance of lipid/protein interactions in the folding, assembly, stability, and function of membrane proteins, information at an atomic level on how such proteins interact with the lipids that surround them remains sparse. The dynamics and flexible nature of the protein/bilayer interaction make it difficult to study, for example, by crystallographic means. However, based on recent progress in molecular simulations of membranes it is possible to address this problem computationally. This communication reports one of the first attempts to use multiple ns molecular simulations to establish a qualitative picture of the intermolecular interactions between the lipids of a bilayer and two topologically different membrane proteins for which a high resolution (2 A or better) X-ray structure is available. |
| spellingShingle | Domene, C Bond, P Deol, S Sansom, MS Lipid/protein interactions and the membrane/water interfacial region. |
| title | Lipid/protein interactions and the membrane/water interfacial region. |
| title_full | Lipid/protein interactions and the membrane/water interfacial region. |
| title_fullStr | Lipid/protein interactions and the membrane/water interfacial region. |
| title_full_unstemmed | Lipid/protein interactions and the membrane/water interfacial region. |
| title_short | Lipid/protein interactions and the membrane/water interfacial region. |
| title_sort | lipid protein interactions and the membrane water interfacial region |
| work_keys_str_mv | AT domenec lipidproteininteractionsandthemembranewaterinterfacialregion AT bondp lipidproteininteractionsandthemembranewaterinterfacialregion AT deols lipidproteininteractionsandthemembranewaterinterfacialregion AT sansomms lipidproteininteractionsandthemembranewaterinterfacialregion |