Metabolism in the tumour-bone microenvironment
Purpose of Review For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease. The impor...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer
2021
|
| _version_ | 1797069626447757312 |
|---|---|
| author | Whitburn, J Edwards, CM |
| author_facet | Whitburn, J Edwards, CM |
| author_sort | Whitburn, J |
| collection | OXFORD |
| description | Purpose of Review
For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease. The importance of metabolic reprogramming is becoming increasingly recognised, particularly within cancer biology, enabling tumours to adapt to changing environments and pressures. This review will discuss our current understanding of metabolic requirements and adaptations within the tumour-bone microenvironment.
<br>
Recent Findings
The bone provides a unique metabolic microenvironment, home to highly energy-intensive processes such as bone resorption and bone formation, both of which are dysregulated in the presence of cancer. Approaches such as metabolomics demonstrate metabolic plasticity in patients with advanced disease. Metabolic crosstalk between tumour cells and surrounding stroma supports disease pathogenesis.
<br>
Summary
There is increasing evidence for a key role for metabolic reprogramming within the tumour-bone microenvironment to drive disease progression. As such, understanding these metabolic adaptations should reveal new therapeutic targets and approaches. |
| first_indexed | 2024-03-06T22:27:15Z |
| format | Journal article |
| id | oxford-uuid:571186e8-32c5-492f-be44-89a8f08f5673 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:27:15Z |
| publishDate | 2021 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:571186e8-32c5-492f-be44-89a8f08f56732022-03-26T16:54:23ZMetabolism in the tumour-bone microenvironmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:571186e8-32c5-492f-be44-89a8f08f5673EnglishSymplectic ElementsSpringer2021Whitburn, JEdwards, CMPurpose of Review For solid tumours such as breast and prostate cancer, and haematological malignancies such as myeloma, bone represents a supportive home, where the cellular crosstalk is known to underlie both tumour growth and survival, and the development of the associated bone disease. The importance of metabolic reprogramming is becoming increasingly recognised, particularly within cancer biology, enabling tumours to adapt to changing environments and pressures. This review will discuss our current understanding of metabolic requirements and adaptations within the tumour-bone microenvironment. <br> Recent Findings The bone provides a unique metabolic microenvironment, home to highly energy-intensive processes such as bone resorption and bone formation, both of which are dysregulated in the presence of cancer. Approaches such as metabolomics demonstrate metabolic plasticity in patients with advanced disease. Metabolic crosstalk between tumour cells and surrounding stroma supports disease pathogenesis. <br> Summary There is increasing evidence for a key role for metabolic reprogramming within the tumour-bone microenvironment to drive disease progression. As such, understanding these metabolic adaptations should reveal new therapeutic targets and approaches. |
| spellingShingle | Whitburn, J Edwards, CM Metabolism in the tumour-bone microenvironment |
| title | Metabolism in the tumour-bone microenvironment |
| title_full | Metabolism in the tumour-bone microenvironment |
| title_fullStr | Metabolism in the tumour-bone microenvironment |
| title_full_unstemmed | Metabolism in the tumour-bone microenvironment |
| title_short | Metabolism in the tumour-bone microenvironment |
| title_sort | metabolism in the tumour bone microenvironment |
| work_keys_str_mv | AT whitburnj metabolisminthetumourbonemicroenvironment AT edwardscm metabolisminthetumourbonemicroenvironment |