PPARs and adipocyte function.
For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated recep...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797069648624091136 |
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| author | Christodoulides, C Vidal-Puig, A |
| author_facet | Christodoulides, C Vidal-Puig, A |
| author_sort | Christodoulides, C |
| collection | OXFORD |
| description | For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology. |
| first_indexed | 2024-03-06T22:27:34Z |
| format | Journal article |
| id | oxford-uuid:572d9a53-6137-4d5a-80e3-a40e7d364fee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:27:34Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:572d9a53-6137-4d5a-80e3-a40e7d364fee2022-03-26T16:55:02ZPPARs and adipocyte function.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:572d9a53-6137-4d5a-80e3-a40e7d364feeEnglishSymplectic Elements at Oxford2010Christodoulides, CVidal-Puig, AFor long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology. |
| spellingShingle | Christodoulides, C Vidal-Puig, A PPARs and adipocyte function. |
| title | PPARs and adipocyte function. |
| title_full | PPARs and adipocyte function. |
| title_fullStr | PPARs and adipocyte function. |
| title_full_unstemmed | PPARs and adipocyte function. |
| title_short | PPARs and adipocyte function. |
| title_sort | ppars and adipocyte function |
| work_keys_str_mv | AT christodoulidesc pparsandadipocytefunction AT vidalpuiga pparsandadipocytefunction |