Triplex-directed covalent cross-linking of a DNA nanostructure.

The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups...

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Bibliographic Details
Main Authors: Rusling, D, Nandhakumar, I, Brown, T, Fox, K
Format: Journal article
Language:English
Published: 2012
Description
Summary:The triplex approach to DNA recognition is exploited to direct covalent inter-strand cross-links to unique locations within a pre-assembled DNA nanostructure. This approach can be used to improve the stability of DNA nanostructures and demonstrates the feasibility of directing other reactive groups to unique locations within these complexes.