CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memory to reject returning invaders. Both the Cascade ribonucleoprotein complex and the Cas3 nuclease/helicas...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Westra, E, van Erp, P, Künne, T, Wong, S, Staals, R, Seegers, C, Bollen, S, Jore, M, Semenova, E, Severinov, K, de Vos, WM, Dame, RT, de Vries, R, Brouns, S, van der Oost, J
Format:	Journal article
Język:	English
Wydane:	2012

CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.

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