Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard.
Early detection and confirmation of cholera outbreaks are crucial for rapid implementation of control measures. Because cholera frequently affects regions with limited laboratory resources, rapid diagnostic tests (RDT) designed for field conditions are important to enhance rapid response. Stool cult...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2012
|
| _version_ | 1826273462911500288 |
|---|---|
| author | Page, A Alberti, K Mondonge, V Rauzier, J Quilici, M Guerin, P |
| author_facet | Page, A Alberti, K Mondonge, V Rauzier, J Quilici, M Guerin, P |
| author_sort | Page, A |
| collection | OXFORD |
| description | Early detection and confirmation of cholera outbreaks are crucial for rapid implementation of control measures. Because cholera frequently affects regions with limited laboratory resources, rapid diagnostic tests (RDT) designed for field conditions are important to enhance rapid response. Stool culture remains the "gold standard" for cholera diagnosis; however, its lack of sensitivity may lead to underestimation of test specificity. We evaluated the Crystal VC(r) immunochromatographic test (Span Diagnostics, India) for cholera diagnosis using a modified reference standard that combines culture-dependent and independent assays, or a Bayesian latent class model (LCM) analysis. |
| first_indexed | 2024-03-06T22:28:33Z |
| format | Journal article |
| id | oxford-uuid:577e59cf-4b1a-4870-b830-cca36552d65b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:28:33Z |
| publishDate | 2012 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:577e59cf-4b1a-4870-b830-cca36552d65b2022-03-26T16:57:06ZEvaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:577e59cf-4b1a-4870-b830-cca36552d65bEnglishSymplectic Elements at OxfordPublic Library of Science2012Page, AAlberti, KMondonge, VRauzier, JQuilici, MGuerin, PEarly detection and confirmation of cholera outbreaks are crucial for rapid implementation of control measures. Because cholera frequently affects regions with limited laboratory resources, rapid diagnostic tests (RDT) designed for field conditions are important to enhance rapid response. Stool culture remains the "gold standard" for cholera diagnosis; however, its lack of sensitivity may lead to underestimation of test specificity. We evaluated the Crystal VC(r) immunochromatographic test (Span Diagnostics, India) for cholera diagnosis using a modified reference standard that combines culture-dependent and independent assays, or a Bayesian latent class model (LCM) analysis. |
| spellingShingle | Page, A Alberti, K Mondonge, V Rauzier, J Quilici, M Guerin, P Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title | Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title_full | Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title_fullStr | Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title_full_unstemmed | Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title_short | Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard. |
| title_sort | evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard |
| work_keys_str_mv | AT pagea evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard AT albertik evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard AT mondongev evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard AT rauzierj evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard AT quilicim evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard AT guerinp evaluationofarapidtestforthediagnosisofcholeraintheabsenceofagoldstandard |