The mechanism of Nov (CCN3) function in haematopoiesis
<p>Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study id...
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| Format: | Thesis |
| Language: | English |
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2012
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| _version_ | 1826273468570664960 |
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| author | Guo, Y |
| author2 | Enver, T |
| author_facet | Enver, T Guo, Y |
| author_sort | Guo, Y |
| collection | OXFORD |
| description | <p>Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified <em>Nov</em> as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.</p> |
| first_indexed | 2024-03-06T22:28:38Z |
| format | Thesis |
| id | oxford-uuid:5785f3b9-3206-4bb4-b486-d90cded680f8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:28:38Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5785f3b9-3206-4bb4-b486-d90cded680f82022-03-26T16:57:17ZThe mechanism of Nov (CCN3) function in haematopoiesisThesishttp://purl.org/coar/resource_type/c_db06uuid:5785f3b9-3206-4bb4-b486-d90cded680f8Cell Biology (see also Plant sciences)BloodHaematologyStem cells (clinical sciences)EnglishOxford University Research Archive - Valet2012Guo, YEnver, TVyas, P<p>Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified <em>Nov</em> as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.</p> |
| spellingShingle | Cell Biology (see also Plant sciences) Blood Haematology Stem cells (clinical sciences) Guo, Y The mechanism of Nov (CCN3) function in haematopoiesis |
| title | The mechanism of Nov (CCN3) function in haematopoiesis |
| title_full | The mechanism of Nov (CCN3) function in haematopoiesis |
| title_fullStr | The mechanism of Nov (CCN3) function in haematopoiesis |
| title_full_unstemmed | The mechanism of Nov (CCN3) function in haematopoiesis |
| title_short | The mechanism of Nov (CCN3) function in haematopoiesis |
| title_sort | mechanism of nov ccn3 function in haematopoiesis |
| topic | Cell Biology (see also Plant sciences) Blood Haematology Stem cells (clinical sciences) |
| work_keys_str_mv | AT guoy themechanismofnovccn3functioninhaematopoiesis AT guoy mechanismofnovccn3functioninhaematopoiesis |