Ancient chicken remains reveal the origins of virulence in Marek’s disease virus
The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past c...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2023
|
| _version_ | 1811139489718861824 |
|---|---|
| author | Fiddaman, SR Dimopoulos, EA Lebrasseur, O du Plessis, L Vrancken, B Charlton, S Haruda, AF Tabbada, K Flammer, PG Dascalu, S Marković, N Li, H Franklin, G Symmons, R Baron, H Daróczi-Szabó, L Shaymuratova, DN Askeyev, IV Putelat, O Sana, M Davoudi, H Fathi, H Mucheshi, AS Vahdati, AA Zhang, L Foster, A Sykes, N Baumberg, GC Bulatović, J Askeyev, AO Askeyev, OV Mashkour, M Pybus, OG Nair, V Larson, G Smith, AL Frantz, LAF |
| author_facet | Fiddaman, SR Dimopoulos, EA Lebrasseur, O du Plessis, L Vrancken, B Charlton, S Haruda, AF Tabbada, K Flammer, PG Dascalu, S Marković, N Li, H Franklin, G Symmons, R Baron, H Daróczi-Szabó, L Shaymuratova, DN Askeyev, IV Putelat, O Sana, M Davoudi, H Fathi, H Mucheshi, AS Vahdati, AA Zhang, L Foster, A Sykes, N Baumberg, GC Bulatović, J Askeyev, AO Askeyev, OV Mashkour, M Pybus, OG Nair, V Larson, G Smith, AL Frantz, LAF |
| author_sort | Fiddaman, SR |
| collection | OXFORD |
| description | The pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens. |
| first_indexed | 2024-03-07T08:15:32Z |
| format | Journal article |
| id | oxford-uuid:579f0df9-138e-4187-8203-74f3ff756a14 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:06:54Z |
| publishDate | 2023 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:579f0df9-138e-4187-8203-74f3ff756a142024-06-03T13:48:41ZAncient chicken remains reveal the origins of virulence in Marek’s disease virusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:579f0df9-138e-4187-8203-74f3ff756a14EnglishSymplectic ElementsAmerican Association for the Advancement of Science2023Fiddaman, SRDimopoulos, EALebrasseur, Odu Plessis, LVrancken, BCharlton, SHaruda, AFTabbada, KFlammer, PGDascalu, SMarković, NLi, HFranklin, GSymmons, RBaron, HDaróczi-Szabó, LShaymuratova, DNAskeyev, IVPutelat, OSana, MDavoudi, HFathi, HMucheshi, ASVahdati, AAZhang, LFoster, ASykes, NBaumberg, GCBulatović, JAskeyev, AOAskeyev, OVMashkour, MPybus, OGNair, VLarson, GSmith, ALFrantz, LAFThe pronounced growth in livestock populations since the 1950s has altered the epidemiological and evolutionary trajectory of their associated pathogens. For example, Marek’s disease virus (MDV), which causes lymphoid tumors in chickens, has experienced a marked increase in virulence over the past century. Today, MDV infections kill >90% of unvaccinated birds, and controlling it costs more than US$1 billion annually. By sequencing MDV genomes derived from archeological chickens, we demonstrate that it has been circulating for at least 1000 years. We functionally tested the Meq oncogene, one of 49 viral genes positively selected in modern strains, demonstrating that ancient MDV was likely incapable of driving tumor formation. Our results demonstrate the power of ancient DNA approaches to trace the molecular basis of virulence in economically relevant pathogens. |
| spellingShingle | Fiddaman, SR Dimopoulos, EA Lebrasseur, O du Plessis, L Vrancken, B Charlton, S Haruda, AF Tabbada, K Flammer, PG Dascalu, S Marković, N Li, H Franklin, G Symmons, R Baron, H Daróczi-Szabó, L Shaymuratova, DN Askeyev, IV Putelat, O Sana, M Davoudi, H Fathi, H Mucheshi, AS Vahdati, AA Zhang, L Foster, A Sykes, N Baumberg, GC Bulatović, J Askeyev, AO Askeyev, OV Mashkour, M Pybus, OG Nair, V Larson, G Smith, AL Frantz, LAF Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title | Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title_full | Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title_fullStr | Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title_full_unstemmed | Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title_short | Ancient chicken remains reveal the origins of virulence in Marek’s disease virus |
| title_sort | ancient chicken remains reveal the origins of virulence in marek s disease virus |
| work_keys_str_mv | AT fiddamansr ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT dimopoulosea ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT lebrasseuro ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT duplessisl ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT vranckenb ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT charltons ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT harudaaf ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT tabbadak ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT flammerpg ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT dascalus ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT markovicn ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT lih ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT frankling ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT symmonsr ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT baronh ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT darocziszabol ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT shaymuratovadn ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT askeyeviv ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT putelato ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT sanam ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT davoudih ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT fathih ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT mucheshias ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT vahdatiaa ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT zhangl ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT fostera ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT sykesn ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT baumberggc ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT bulatovicj ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT askeyevao ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT askeyevov ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT mashkourm ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT pybusog ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT nairv ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT larsong ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT smithal ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus AT frantzlaf ancientchickenremainsrevealtheoriginsofvirulenceinmareksdiseasevirus |