An induced rebinding model of antigen discrimination

An induced rebinding model of antigen discrimination

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T cells have to detect rare high-affinity 'foreign' peptide MHC (pMHC) ligands among abundant low-affinity 'self'-peptide MHC ligands. It remains unclear how this remarkable discrimination is achieved. Kinetic proofreading mechanisms can provide the required specificity but only...

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Dettagli Bibliografici
Autori principali:	Dushek, O, Van der Merwe, P
Natura:	Journal article
Lingua:	English
Pubblicazione:	Elsevier 2014

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