A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advanced adenomas) and 965 controls. We evaluated selected SNPs in three replication sample sets (7,473 cas...

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Autors principals: Broderick, P, Carvajal-Carmona, L, Pittman, A, Webb, E, Howarth, K, Rowan, A, Lubbe, S, Spain, S, Sullivan, K, Fielding, S, Jaeger, E, Vijayakrishnan, J, Kemp, Z, Gorman, M, Chandler, I, Papaemmanuil, E, Penegar, S, Wood, W, Sellick, G, Qureshi, M, Teixeira, A, Domingo, E, Barclay, E, Martin, L, Sieber, O
Format: Journal article
Idioma:English
Publicat: 2007

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