Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes

Ivermectin for COVID-19 in adults in the community (PRINCIPLE): an open, randomised, controlled, adaptive platform trial of short- and longer-term outcomes

<strong>Background<br></strong> The evidence for whether ivermectin impacts recovery, hospital admissions, and longer-term outcomes in COVID-19 is contested. The WHO recommends its use only in the context of clinical trials. <br><strong> Methods<br></strong>...

Descripció completa

Dades bibliogràfiques
Autors principals:	Hayward, G, Yu, L-M, Little, P, Gbinigie, O, Shanyinde, M, Harris, V, Dorward, J, Saville, BR, Berry, N, Evans, PH, Thomas, NP, Patel, MG, Richards, D, van Hecke, O, Detry, MA, Saunders, C, Fitzgerald, M, Robinson, J, Latimer-Bell, C, Allen, J, Ogburn, E, Grabey, J, de Lusignan, S, Hobbs, FR, Butler, CC
Altres autors:	PRINCIPLE Trial Collaborative Group
Format:	Journal article
Idioma:	English
Publicat:	Elsevier 2024

Ítems similars

Inhaled budesonide for COVID-19 in people at higher risk of complications in the community: the UK National Community Randomi
per: Gbinigie, O, et al.
Publicat: (2023)

Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
per: Butler, CC, et al.
Publicat: (2021)

Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
per: PRINCIPLE Trial Collaborative Group, et al.
Publicat: (2021)

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
per: Yu, L-M, et al.
Publicat: (2021)

Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
per: Dorward, J, et al.
Publicat: (2022)

Colchicine for COVID-19 in adults in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial
per: PRINCIPLE Trial Collaborative Group, et al.
Publicat: (2021)

Inhaled budesonide for COVID-19 in people at higher risk of adverse outcomes in the community: interim analyses from the PRINCIPLE trial
per: Yu, L-M, et al.
Publicat: (2021)

Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk
per: Hayward, G, et al.
Publicat: (2021)

Identification of the metabolites of ivermectin in humans
per: Tipthara, P, et al.
Publicat: (2021)

Ivermectin metabolites reduce Anopheles survival
per: Kobylinski, KC, et al.
Publicat: (2023)

The protease inhibitor lopinavir, boosted with ritonavir, as treatment for COVID-19: A rapid review
per: Dorward, J, et al.
Publicat: (2021)

Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s.
per: Kiuru, C, et al.
Publicat: (2023)

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study.
per: de Lusignan, S, et al.
Publicat: (2021)

Effect of ivermectin on sarcoptic mange lesions of goats
per: Zamri-Saad, M., et al.
Publicat: (1990)

Ivermectin resistance mechanisms in ectoparasites: a scoping review
per: Furnival-Adams, J, et al.
Publicat: (2024)

Computational Prediction of the Interaction of Ivermectin with Fibrinogen
per: Vottero, Paola, et al.
Publicat: (2023)

Aedes aegypti (L.) survival after exposure to ivermectin.
per: Whitehorn, J, et al.
Publicat: (2013)

Aedes aegypti (L.) survival after exposure to ivermectin
per: Whitehorn, J, et al.
Publicat: (2013)

Overview of systematic reviews assessing the evidence for shorter versus longer duration antibiotic treatment for bacterial infections in secondary care.
per: Onakpoya, I, et al.
Publicat: (2018)

More social species live longer, have longer generation times, and longer reproductive windows
per: Salguero-Gomez, R
Publicat: (2024)

The longer reach/
per: 179100 Piper, David Warren
Publicat: (1974)

Live longer /
per: Alder, Harry, Dr. 289476
Publicat: (2005)

Dying later, surviving longer
per: Wilkinson, D, et al.
Publicat: (2016)

The pharmacokinetics and drug-drug interactions of ivermectin in Aedes aegypti mosquitoes
per: Duthaler, U, et al.
Publicat: (2021)

Ivermectin inhibits molting of Wuchereria bancrofti third stage larvae in vitro.
per: Baird, J, et al.
Publicat: (1991)

Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles.
per: Kobylinski, KC, et al.
Publicat: (2016)

Persistent effect of ivermectin against Haemonchus contortus in goats.
per: Abdullah Sani, Rehana, et al.
Publicat: (1989)

Detection of resistance of gastrointestinal nematodes to albendazole and ivermectin in goats
per: Hassan Basri, Basripuzi Nurul Hayyan, et al.
Publicat: (2010)

Better night lights data, for longer
per: Gibson, J
Publicat: (2020)

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship
per: de Lusignan, S, et al.
Publicat: (2021)

A field bioassay for assessing ivermectin bio-efficacy in wild malaria vectors
per: Ominde, KM, et al.
Publicat: (2023)

EFEKTIVITAS IVERMECTIN DAN FIPRONIL DALAM MENGATASI SERANGAN CAPLAK PADA ANJING = THE EFFECTIVENESS OF IVERMECTIN AND F1PRONIL FOR TICK ERADICATION IN DOG
per: Purnamaningsih, Hary, et al.
Publicat: (2002)

EFEKTIVITAS IVERMECTIN DAN FIPRONIL DALAM MENGATASI SERANGAN CAPLAK PADA ANJING = THE EFFECTIVENESS OF IVERMECTIN AND F1PRONIL FOR TICK ERADICATION IN DOG
per: Perpustakaan UGM, i-lib
Publicat: (2002)

Impact of ivermectin components on Anopheles dirus and Anopheles minimus mosquito survival
per: Khemrattrakool, P, et al.
Publicat: (2024)

Longer period needed
per: Pfordten, Diyana
Publicat: (2021)

Romberg’s test no longer stands up
per: Turner, M
Publicat: (2016)

Varsity practical training to be longer
per: New Straits Times,
Publicat: (2016)

Middleboxes No Longer Considered Harmful
per: Walfish, Michael, et al.
Publicat: (2005)

Food supplements no longer an option /
per: 309186 Miller, Bruce B.
Publicat: (1996)

Longer life and healthy aging /
per: Yi, Zeng
Publicat: (2006)