An efficient asymmetric synthesis of (-)-lupinine.

The asymmetric synthesis of (-)-lupinine was achieved in 8 steps, 15% overall yield and >99 : 1 dr from commercially available starting materials. The strategy used for the construction of the quinolizidine scaffold involved reaction of an enantiopure tertiary dibenzylamine via two sequential...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Davies, S, Fletcher, A, Foster, E, Houlsby, I, Roberts, P, Schofield, T, Thomson, J
Format: Journal article
Język:English
Wydane: Royal Society of Chemistry 2014
Opis
Streszczenie:The asymmetric synthesis of (-)-lupinine was achieved in 8 steps, 15% overall yield and >99 : 1 dr from commercially available starting materials. The strategy used for the construction of the quinolizidine scaffold involved reaction of an enantiopure tertiary dibenzylamine via two sequential ring-closures which both occurred with concomitant N-debenzylation.