Incidence and prevalence of NMOSD in Australia and New Zealand
<h4>Objectives</h4> <p>We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry.</p> <h4>Background</h4&...
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| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2017
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| _version_ | 1797069824289931264 |
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| author | Bukhari, W Prain, KM Waters, P Woodhall, M O'Gorman, CM Clarke, L Silvestrini, RA Bundell, CS Abernethy, D Bhuta, S Blum, S Boggild, M Boundy, K Brew, BJ Brown, M Brownlee, WJ Butzkueven, H Carroll, WM Chen, C Coulthard, A Dale, RC Das, C Dear, K Fabis-Pedrini, MJ Fulcher, D Gillis, D Hawke, S Heard, R Henderson, APD Heshmat, S Hodgkinson, S Jimenez-Sanchez, S Killpatrick, T King, J Kneebone, C Kornberg, AJ Lechner-Scott, J Lin, M-W Lynch, C Macdonell, R Mason, DF McCombe, PA Pender, MP Pereira, JA Pollard, JD Reddel, SW Shaw, C Spies, J Stankovich, J Sutton, I Vucic, S Walsh, M Wong, RC Yiu, EM Barnett, MH Kermode, AG Marriott, MP Parratt, JDE Slee, M Taylor, BV Willoughby, E Wilson, RJ Vincent, A Broadley, SA |
| author_facet | Bukhari, W Prain, KM Waters, P Woodhall, M O'Gorman, CM Clarke, L Silvestrini, RA Bundell, CS Abernethy, D Bhuta, S Blum, S Boggild, M Boundy, K Brew, BJ Brown, M Brownlee, WJ Butzkueven, H Carroll, WM Chen, C Coulthard, A Dale, RC Das, C Dear, K Fabis-Pedrini, MJ Fulcher, D Gillis, D Hawke, S Heard, R Henderson, APD Heshmat, S Hodgkinson, S Jimenez-Sanchez, S Killpatrick, T King, J Kneebone, C Kornberg, AJ Lechner-Scott, J Lin, M-W Lynch, C Macdonell, R Mason, DF McCombe, PA Pender, MP Pereira, JA Pollard, JD Reddel, SW Shaw, C Spies, J Stankovich, J Sutton, I Vucic, S Walsh, M Wong, RC Yiu, EM Barnett, MH Kermode, AG Marriott, MP Parratt, JDE Slee, M Taylor, BV Willoughby, E Wilson, RJ Vincent, A Broadley, SA |
| author_sort | Bukhari, W |
| collection | OXFORD |
| description | <h4>Objectives</h4> <p>We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry.</p> <h4>Background</h4> <p>NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established.</p> <h4>Methods</h4> <p>Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture–recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases.</p> <h4>Results</h4> <p>NMOSD was confirmed in 81/170 (48%) cases referred. Capture–recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD.</p> <h4>Conclusions</h4> <p>NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.</p> |
| first_indexed | 2024-03-06T22:30:10Z |
| format | Journal article |
| id | oxford-uuid:58050765-0835-4384-9f31-1eb4484571a4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:30:10Z |
| publishDate | 2017 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:58050765-0835-4384-9f31-1eb4484571a42022-03-26T17:00:30ZIncidence and prevalence of NMOSD in Australia and New ZealandJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58050765-0835-4384-9f31-1eb4484571a4EnglishSymplectic Elements at OxfordBMJ Publishing Group2017Bukhari, WPrain, KMWaters, PWoodhall, MO'Gorman, CMClarke, LSilvestrini, RABundell, CSAbernethy, DBhuta, SBlum, SBoggild, MBoundy, KBrew, BJBrown, MBrownlee, WJButzkueven, HCarroll, WMChen, CCoulthard, ADale, RCDas, CDear, KFabis-Pedrini, MJFulcher, DGillis, DHawke, SHeard, RHenderson, APDHeshmat, SHodgkinson, SJimenez-Sanchez, SKillpatrick, TKing, JKneebone, CKornberg, AJLechner-Scott, JLin, M-WLynch, CMacdonell, RMason, DFMcCombe, PAPender, MPPereira, JAPollard, JDReddel, SWShaw, CSpies, JStankovich, JSutton, IVucic, SWalsh, MWong, RCYiu, EMBarnett, MHKermode, AGMarriott, MPParratt, JDESlee, MTaylor, BVWilloughby, EWilson, RJVincent, ABroadley, SA <h4>Objectives</h4> <p>We have undertaken a clinic-based survey of neuromyelitis optica spectrum disorders (NMOSDs) in Australia and New Zealand to establish incidence and prevalence across the region and in populations of differing ancestry.</p> <h4>Background</h4> <p>NMOSD is a recently defined demyelinating disease of the central nervous system (CNS). The incidence and prevalence of NMOSD in Australia and New Zealand has not been established.</p> <h4>Methods</h4> <p>Centres managing patients with demyelinating disease of the CNS across Australia and New Zealand reported patients with clinical and laboratory features that were suspicious for NMOSD. Testing for aquaporin 4 antibodies was undertaken in all suspected cases. From this group, cases were identified who fulfilled the 2015 Wingerchuk diagnostic criteria for NMOSD. A capture–recapture methodology was used to estimate incidence and prevalence, based on additional laboratory identified cases.</p> <h4>Results</h4> <p>NMOSD was confirmed in 81/170 (48%) cases referred. Capture–recapture analysis gave an adjusted incidence estimate of 0.37 (95% CI 0.35 to 0.39) per million per year and a prevalence estimate for NMOSD of 0.70 (95% CI 0.61 to 0.78) per 100 000. NMOSD was three times more common in the Asian population (1.57 (95% CI 1.15 to 1.98) per 100 000) compared with the remainder of the population (0.57 (95% CI 0.50 to 0.65) per 100 000). The latitudinal gradient evident in multiple sclerosis was not seen in NMOSD.</p> <h4>Conclusions</h4> <p>NMOSD incidence and prevalence in Australia and New Zealand are comparable with figures from other populations of largely European ancestry. We found NMOSD to be more common in the population with Asian ancestry.</p> |
| spellingShingle | Bukhari, W Prain, KM Waters, P Woodhall, M O'Gorman, CM Clarke, L Silvestrini, RA Bundell, CS Abernethy, D Bhuta, S Blum, S Boggild, M Boundy, K Brew, BJ Brown, M Brownlee, WJ Butzkueven, H Carroll, WM Chen, C Coulthard, A Dale, RC Das, C Dear, K Fabis-Pedrini, MJ Fulcher, D Gillis, D Hawke, S Heard, R Henderson, APD Heshmat, S Hodgkinson, S Jimenez-Sanchez, S Killpatrick, T King, J Kneebone, C Kornberg, AJ Lechner-Scott, J Lin, M-W Lynch, C Macdonell, R Mason, DF McCombe, PA Pender, MP Pereira, JA Pollard, JD Reddel, SW Shaw, C Spies, J Stankovich, J Sutton, I Vucic, S Walsh, M Wong, RC Yiu, EM Barnett, MH Kermode, AG Marriott, MP Parratt, JDE Slee, M Taylor, BV Willoughby, E Wilson, RJ Vincent, A Broadley, SA Incidence and prevalence of NMOSD in Australia and New Zealand |
| title | Incidence and prevalence of NMOSD in Australia and New Zealand |
| title_full | Incidence and prevalence of NMOSD in Australia and New Zealand |
| title_fullStr | Incidence and prevalence of NMOSD in Australia and New Zealand |
| title_full_unstemmed | Incidence and prevalence of NMOSD in Australia and New Zealand |
| title_short | Incidence and prevalence of NMOSD in Australia and New Zealand |
| title_sort | incidence and prevalence of nmosd in australia and new zealand |
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