Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells.
Memory or antigen-experienced CD4 T cells differ from naive CD4 T cells both phenotypically by cell surface marker expression, and functionally by their dissimilar pattern of cytokine secretion and activation requirements through their T cell receptor (TCR). We show here that activation of memory CD...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1995
|
| _version_ | 1797069828693950464 |
|---|---|
| author | Farber, D Luqman, M Acuto, O Bottomly, K |
| author_facet | Farber, D Luqman, M Acuto, O Bottomly, K |
| author_sort | Farber, D |
| collection | OXFORD |
| description | Memory or antigen-experienced CD4 T cells differ from naive CD4 T cells both phenotypically by cell surface marker expression, and functionally by their dissimilar pattern of cytokine secretion and activation requirements through their T cell receptor (TCR). We show here that activation of memory CD4 T cells (CD45RBlo subset), but not naive CD4 T cells (CD45RBhi subset), is inhibited by MHC class II molecules on antigen-presenting cells and by CD4 ligation. We propose that the selective negative signal in memory cells is a direct result of the differences in signaling via CD4 and CD3, exemplified in the disparate pattern of tyrosine-phosphorylated proteins visible after activation of the two subsets. In vivo, this inhibitory signal may serve to prevent irrelevant interactions between memory CD4 T cells and bystander MHC class II+ cells, and may also be responsible for the defective functioning of memory CD4 T cells in AIDS. |
| first_indexed | 2024-03-06T22:30:14Z |
| format | Journal article |
| id | oxford-uuid:5808fb22-829b-4eea-9323-1abf5711e808 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:30:14Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:5808fb22-829b-4eea-9323-1abf5711e8082022-03-26T17:00:31ZControl of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5808fb22-829b-4eea-9323-1abf5711e808EnglishSymplectic Elements at Oxford1995Farber, DLuqman, MAcuto, OBottomly, KMemory or antigen-experienced CD4 T cells differ from naive CD4 T cells both phenotypically by cell surface marker expression, and functionally by their dissimilar pattern of cytokine secretion and activation requirements through their T cell receptor (TCR). We show here that activation of memory CD4 T cells (CD45RBlo subset), but not naive CD4 T cells (CD45RBhi subset), is inhibited by MHC class II molecules on antigen-presenting cells and by CD4 ligation. We propose that the selective negative signal in memory cells is a direct result of the differences in signaling via CD4 and CD3, exemplified in the disparate pattern of tyrosine-phosphorylated proteins visible after activation of the two subsets. In vivo, this inhibitory signal may serve to prevent irrelevant interactions between memory CD4 T cells and bystander MHC class II+ cells, and may also be responsible for the defective functioning of memory CD4 T cells in AIDS. |
| spellingShingle | Farber, D Luqman, M Acuto, O Bottomly, K Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title | Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title_full | Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title_fullStr | Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title_full_unstemmed | Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title_short | Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. |
| title_sort | control of memory cd4 t cell activation mhc class ii molecules on apcs and cd4 ligation inhibit memory but not naive cd4 t cells |
| work_keys_str_mv | AT farberd controlofmemorycd4tcellactivationmhcclassiimoleculesonapcsandcd4ligationinhibitmemorybutnotnaivecd4tcells AT luqmanm controlofmemorycd4tcellactivationmhcclassiimoleculesonapcsandcd4ligationinhibitmemorybutnotnaivecd4tcells AT acutoo controlofmemorycd4tcellactivationmhcclassiimoleculesonapcsandcd4ligationinhibitmemorybutnotnaivecd4tcells AT bottomlyk controlofmemorycd4tcellactivationmhcclassiimoleculesonapcsandcd4ligationinhibitmemorybutnotnaivecd4tcells |