Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1.
(Figure Presented) Dumbbells that block: Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methy...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1797069837743161344 |
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| author | Kuch, D Schermelleh, L Manetto, S Leonhardt, H Carell, T |
| author_facet | Kuch, D Schermelleh, L Manetto, S Leonhardt, H Carell, T |
| author_sort | Kuch, D |
| collection | OXFORD |
| description | (Figure Presented) Dumbbells that block: Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S-adenosylmethionine, Fl=Cy3 fluorescence label, CN=5-azadC, C-Me=5-methyldC). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA. |
| first_indexed | 2024-03-06T22:30:22Z |
| format | Journal article |
| id | oxford-uuid:58124828-f539-4391-b44f-f0e649f0acc7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:30:22Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:58124828-f539-4391-b44f-f0e649f0acc72022-03-26T17:00:51ZSynthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58124828-f539-4391-b44f-f0e649f0acc7EnglishSymplectic Elements at Oxford2008Kuch, DSchermelleh, LManetto, SLeonhardt, HCarell, T(Figure Presented) Dumbbells that block: Dnmt1 is a crucial enzyme in maintaining the methylation pattern of genes and as such is a critical element of the epigenetic programming process. DNA dumbbell constructs have been developed that inhibit Dnmt1 and have potential in the regulation of DNA methylation patterns in cells (see scheme; SAM=S-adenosylmethionine, Fl=Cy3 fluorescence label, CN=5-azadC, C-Me=5-methyldC). © 2008 Wiley-VCH Verlag GmbH and Co. KGaA. |
| spellingShingle | Kuch, D Schermelleh, L Manetto, S Leonhardt, H Carell, T Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title | Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title_full | Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title_fullStr | Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title_full_unstemmed | Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title_short | Synthesis of DNA dumbbell based inhibitors for the human DNA methyltransferase Dnmt1. |
| title_sort | synthesis of dna dumbbell based inhibitors for the human dna methyltransferase dnmt1 |
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