Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media †
Combining the potency of non-covalent halogen bonding (XB) with metal ion coordination, the synthesis and characterisation of a series of hydrophilic XB tripodal Cu(ii) metallo-receptors, strategically designed for tetrahedral anion guest binding and sensing in aqueous media is described. The report...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2024
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| _version_ | 1811139922250170368 |
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| author | Bagha, H Hein, R Lim, JYC Myers, WK Sambrook, MR Beer, PD |
| author_facet | Bagha, H Hein, R Lim, JYC Myers, WK Sambrook, MR Beer, PD |
| author_sort | Bagha, H |
| collection | OXFORD |
| description | Combining the potency of non-covalent halogen bonding (XB) with metal ion coordination, the synthesis and characterisation of a series of hydrophilic XB tripodal Cu(ii) metallo-receptors, strategically designed for tetrahedral anion guest binding and sensing in aqueous media is described. The reported metallo-hosts contain a tripodal C3-symmetric tris-iodotriazole XB donor anion recognition motif terminally functionalised with tri(ethylene glycol) and permethylated β-cyclodextrin functionalities to impart aqueous solubility. Optical UV-vis anion binding studies in combination with unprecedented quantitative EPR anion titration investigations reveal the XB Cu(ii) metallo-receptors exhibit strong and selective phosphate recognition over a range of other monocharged anionic species in competitive aqueous solution containing 40% water, notably outperforming a hydrogen bonding (HB) Cu(ii) metallo-receptor counterpart. Electrochemical studies demonstrate further the capability of the metallo-receptors to sense anions via significant cathodic perturbations of the respective Cu(ii)/Cu(i) redox couple. |
| first_indexed | 2024-09-25T04:13:47Z |
| format | Journal article |
| id | oxford-uuid:582bc47a-1f5d-4d6c-83cd-60929d2b1864 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:13:47Z |
| publishDate | 2024 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:582bc47a-1f5d-4d6c-83cd-60929d2b18642024-07-10T20:22:33ZPhosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media †Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:582bc47a-1f5d-4d6c-83cd-60929d2b1864EnglishJisc Publications RouterRoyal Society of Chemistry2024Bagha, HHein, RLim, JYCMyers, WKSambrook, MRBeer, PDCombining the potency of non-covalent halogen bonding (XB) with metal ion coordination, the synthesis and characterisation of a series of hydrophilic XB tripodal Cu(ii) metallo-receptors, strategically designed for tetrahedral anion guest binding and sensing in aqueous media is described. The reported metallo-hosts contain a tripodal C3-symmetric tris-iodotriazole XB donor anion recognition motif terminally functionalised with tri(ethylene glycol) and permethylated β-cyclodextrin functionalities to impart aqueous solubility. Optical UV-vis anion binding studies in combination with unprecedented quantitative EPR anion titration investigations reveal the XB Cu(ii) metallo-receptors exhibit strong and selective phosphate recognition over a range of other monocharged anionic species in competitive aqueous solution containing 40% water, notably outperforming a hydrogen bonding (HB) Cu(ii) metallo-receptor counterpart. Electrochemical studies demonstrate further the capability of the metallo-receptors to sense anions via significant cathodic perturbations of the respective Cu(ii)/Cu(i) redox couple. |
| spellingShingle | Bagha, H Hein, R Lim, JYC Myers, WK Sambrook, MR Beer, PD Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title | Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title_full | Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title_fullStr | Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title_full_unstemmed | Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title_short | Phosphate selective binding and sensing by halogen bonding tripodal copper( ii ) metallo-receptors in aqueous media † |
| title_sort | phosphate selective binding and sensing by halogen bonding tripodal copper ii metallo receptors in aqueous media † |
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