Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item
Item 10 of the Edinburgh Postnatal Depression Scale (EPDS) is intended to assess thoughts of intentional self-harm but may also elicit concerns about accidental self-harm. It does not specifically address suicide ideation but, nonetheless, is sometimes used as an indicator of suicidality. The 9-item...
| मुख्य लेखकों: | , , , |
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| अन्य लेखक: | |
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Springer Nature
2023
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| _version_ | 1826310184005271552 |
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| author | Qiu, X Wu, Y Sun, Y Stein, A |
| author2 | The DEPRESsion Screening Data (DEPRESSD) EPDS Group |
| author_facet | The DEPRESsion Screening Data (DEPRESSD) EPDS Group Qiu, X Wu, Y Sun, Y Stein, A |
| author_sort | Qiu, X |
| collection | OXFORD |
| description | Item 10 of the Edinburgh Postnatal Depression Scale (EPDS) is intended to assess thoughts of intentional self-harm but may also elicit concerns about accidental self-harm. It does not specifically address suicide ideation but, nonetheless, is sometimes used as an indicator of suicidality. The 9-item version of the EPDS (EPDS-9), which omits item 10, is sometimes used in research due to concern about positive endorsements of item 10 and necessary follow-up. We assessed the equivalence of total score correlations and screening accuracy to detect major depression using the EPDS-9 versus full EPDS among pregnant and postpartum women. We searched Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science from database inception to October 3, 2018 for studies that administered the EPDS and conducted diagnostic classification for major depression based on a validated semi-structured or fully structured interview among women aged 18 or older during pregnancy or within 12 months of giving birth. We conducted an individual participant data meta-analysis. We calculated Pearson correlations with 95% prediction interval (PI) between EPDS-9 and full EPDS total scores using a random effects model. Bivariate random-effects models were fitted to assess screening accuracy. Equivalence tests were done by comparing the confidence intervals (CIs) around the pooled sensitivity and specificity differences to the equivalence margin of δ = 0.05. Individual participant data were obtained from 41 eligible studies (10,906 participants, 1407 major depression cases). The correlation between EPDS-9 and full EPDS scores was 0.998 (95% PI 0.991, 0.999). For sensitivity, the EPDS-9 and full EPDS were equivalent for cut-offs 7–12 (difference range − 0.02, 0.01) and the equivalence was indeterminate for cut-offs 13–15 (all differences − 0.04). For specificity, the EPDS-9 and full EPDS were equivalent for all cut-offs (difference range 0.00, 0.01). The EPDS-9 performs similarly to the full EPDS and can be used when there are concerns about the implications of administering EPDS item 10.
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Trial registration: </strong>The original IPDMA was registered in PROSPERO (CRD42015024785). |
| first_indexed | 2024-03-07T07:46:50Z |
| format | Journal article |
| id | oxford-uuid:58352f20-49fe-4bf7-90a2-20a4e6ef3e7d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:46:50Z |
| publishDate | 2023 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:58352f20-49fe-4bf7-90a2-20a4e6ef3e7d2023-06-20T15:02:09ZIndividual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm itemJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58352f20-49fe-4bf7-90a2-20a4e6ef3e7dEnglishSymplectic ElementsSpringer Nature2023Qiu, XWu, YSun, YStein, AThe DEPRESsion Screening Data (DEPRESSD) EPDS GroupItem 10 of the Edinburgh Postnatal Depression Scale (EPDS) is intended to assess thoughts of intentional self-harm but may also elicit concerns about accidental self-harm. It does not specifically address suicide ideation but, nonetheless, is sometimes used as an indicator of suicidality. The 9-item version of the EPDS (EPDS-9), which omits item 10, is sometimes used in research due to concern about positive endorsements of item 10 and necessary follow-up. We assessed the equivalence of total score correlations and screening accuracy to detect major depression using the EPDS-9 versus full EPDS among pregnant and postpartum women. We searched Medline, Medline In-Process and Other Non-Indexed Citations, PsycINFO, and Web of Science from database inception to October 3, 2018 for studies that administered the EPDS and conducted diagnostic classification for major depression based on a validated semi-structured or fully structured interview among women aged 18 or older during pregnancy or within 12 months of giving birth. We conducted an individual participant data meta-analysis. We calculated Pearson correlations with 95% prediction interval (PI) between EPDS-9 and full EPDS total scores using a random effects model. Bivariate random-effects models were fitted to assess screening accuracy. Equivalence tests were done by comparing the confidence intervals (CIs) around the pooled sensitivity and specificity differences to the equivalence margin of δ = 0.05. Individual participant data were obtained from 41 eligible studies (10,906 participants, 1407 major depression cases). The correlation between EPDS-9 and full EPDS scores was 0.998 (95% PI 0.991, 0.999). For sensitivity, the EPDS-9 and full EPDS were equivalent for cut-offs 7–12 (difference range − 0.02, 0.01) and the equivalence was indeterminate for cut-offs 13–15 (all differences − 0.04). For specificity, the EPDS-9 and full EPDS were equivalent for all cut-offs (difference range 0.00, 0.01). The EPDS-9 performs similarly to the full EPDS and can be used when there are concerns about the implications of administering EPDS item 10. <br><strong> Trial registration: </strong>The original IPDMA was registered in PROSPERO (CRD42015024785). |
| spellingShingle | Qiu, X Wu, Y Sun, Y Stein, A Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title | Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title_full | Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title_fullStr | Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title_full_unstemmed | Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title_short | Individual participant data meta-analysis to compare EPDS accuracy to detect major depression with and without the self-harm item |
| title_sort | individual participant data meta analysis to compare epds accuracy to detect major depression with and without the self harm item |
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