Demonstration of A-currents in pancreatic islet cells.
Voltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than -40 mV, reaching a peak amplitude of 120 +/- 34 pA at +6 mV (n = 4), display rapid turn o...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1989
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| _version_ | 1797069873923227648 |
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| author | Smith, P Bokvist, K Rorsman, P |
| author_facet | Smith, P Bokvist, K Rorsman, P |
| author_sort | Smith, P |
| collection | OXFORD |
| description | Voltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than -40 mV, reaching a peak amplitude of 120 +/- 34 pA at +6 mV (n = 4), display rapid turn on (tau = 3.3 +/- 1.1 ms at +6 mV) and inactivate completely within 250 ms (tau = 65 +/- 5 at +6 mV). The current is subject to steady-state inactivation. The midpoint (Vh) of the inactivation curve (h infinity) was observed at -72 +/- 2 mV. The properties of this current resemble those reported for the A-current in neurons. |
| first_indexed | 2024-03-06T22:30:52Z |
| format | Journal article |
| id | oxford-uuid:58399d28-6dcb-46ec-961c-c037c69daad6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:30:52Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:58399d28-6dcb-46ec-961c-c037c69daad62022-03-26T17:01:58ZDemonstration of A-currents in pancreatic islet cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58399d28-6dcb-46ec-961c-c037c69daad6EnglishSymplectic Elements at Oxford1989Smith, PBokvist, KRorsman, PVoltage-activated K+ currents resistant to TEA but blockable by 4-AP were recorded from mouse pancreatic islet cells. These currents first become observable during depolarizations to voltages more positive than -40 mV, reaching a peak amplitude of 120 +/- 34 pA at +6 mV (n = 4), display rapid turn on (tau = 3.3 +/- 1.1 ms at +6 mV) and inactivate completely within 250 ms (tau = 65 +/- 5 at +6 mV). The current is subject to steady-state inactivation. The midpoint (Vh) of the inactivation curve (h infinity) was observed at -72 +/- 2 mV. The properties of this current resemble those reported for the A-current in neurons. |
| spellingShingle | Smith, P Bokvist, K Rorsman, P Demonstration of A-currents in pancreatic islet cells. |
| title | Demonstration of A-currents in pancreatic islet cells. |
| title_full | Demonstration of A-currents in pancreatic islet cells. |
| title_fullStr | Demonstration of A-currents in pancreatic islet cells. |
| title_full_unstemmed | Demonstration of A-currents in pancreatic islet cells. |
| title_short | Demonstration of A-currents in pancreatic islet cells. |
| title_sort | demonstration of a currents in pancreatic islet cells |
| work_keys_str_mv | AT smithp demonstrationofacurrentsinpancreaticisletcells AT bokvistk demonstrationofacurrentsinpancreaticisletcells AT rorsmanp demonstrationofacurrentsinpancreaticisletcells |