A structural biology perspective on bioactive small molecules and their plant targets.

Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discus...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Kumari, S, van der Hoorn, R
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2011
विवरण
सारांश:Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.