A structural biology perspective on bioactive small molecules and their plant targets.

Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discus...

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Detaylı Bibliyografya
Asıl Yazarlar: Kumari, S, van der Hoorn, R
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2011
Diğer Bilgiler
Özet:Structural biology efforts in recent years have generated numerous co-crystal structures of bioactive small molecules interacting with their plant targets. These studies include the targets of various phytohormones, pathogen-derived effectors, herbicides and other bioactive compounds. Here we discuss that this collection of structures contains excellent examples of nine collective observations: molecular glues, allostery, inhibitors, molecular mimicry, promiscuous binding sites, unexpected electron densities, natural selection at atomic resolution, and applications in structure-guided mutagenesis and small molecule design.