In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor–microenvironment interactions

Functional genomic screens in two-dimensional cell culture models are limited in identifying therapeutic targets that influence the tumor microenvironment. By comparing targeted CRISPR–Cas9 screens in a two-dimensional culture with xenografts derived from the same cell line, we identified MEN1 as th...

Full description

Bibliographic Details
Main Authors: Su, P, Liu, Y, Chen, T, Xue, Y, Zeng, Y, Zhu, G, Chen, S, Teng, M, Ci, X, Guo, M, He, MY, Hao, J, Chu, V, Xu, W, Wang, S, Mehdipour, P, Xu, X, Marhon, SA, Soares, F, Pham, N, Wu, BX, Her, PH, Feng, S, Alshamlan, N
Format: Journal article
Language:English
Published: Nature Research 2024

Similar Items

Similar Items