Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.

The classic model of tumor suppression implies that malignant transformation requires full "two-hit" inactivation of a tumor-suppressor gene. However, more recent work in mice has led to the proposal of a "continuum" model that involves more fluid concepts such as gene dosage-sen...

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Bibliographic Details
Main Authors:	Couvé, S, Ladroue, C, Laine, E, Mahtouk, K, Guégan, J, Gad, S, Le Jeune, H, Le Gentil, M, Nuel, G, Kim, W, Lecomte, B, Pagès, J, Collin, C, Lasne, F, Benusiglio, P, Bressac-de Paillerets, B, Feunteun, J, Lazar, V, Gimenez-Roqueplo, A, Mazure, N, Dessen, P, Tchertanov, L, Mole, D, Kaelin, W, Ratcliffe, P
Format:	Journal article
Language:	English
Published:	American Association for Cancer Research Inc. 2014

Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.

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