Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea.
OBJECTIVE: Obstructive sleep apnoea (OSA) is a relatively common condition producing disabling somnolence and profound physiological responses to hypoxaemic episodes during sleep, including significant oscillations in blood pressure. This study aimed to provide controlled data on the interaction bet...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2003
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| _version_ | 1826273654618456064 |
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| author | Meston, N Davies, R Mullins, R Jenkinson, C Wass, J Stradling, JR |
| author_facet | Meston, N Davies, R Mullins, R Jenkinson, C Wass, J Stradling, JR |
| author_sort | Meston, N |
| collection | OXFORD |
| description | OBJECTIVE: Obstructive sleep apnoea (OSA) is a relatively common condition producing disabling somnolence and profound physiological responses to hypoxaemic episodes during sleep, including significant oscillations in blood pressure. This study aimed to provide controlled data on the interaction between OSA and endocrine axes to establish whether overrepresentation of pathology such as hypertension and hypogonadism in OSA subjects might have an endocrine basis. DESIGN, SETTING AND SUBJECTS: Parallel randomized sham placebo controlled 1-month trial of nasal continuous positive airway pressure (nCPAP) in 101 male subjects with OSA presenting to a respiratory sleep clinic. METHODS: Analysis of gonadotrophins, testosterone, sex hormone binding protein (SHBG), prolactin, cortisol, thyroid stimulating hormone (TSH), free thyroxine (free T4), insulin-like growth factor-1 (IGF-1), renin and aldosterone were performed at baseline and after 1 month's active or placebo nCPAP intervention. Quality of life questionnaire scoring was also recorded over the same time period. RESULTS: Testosterone and SHBG showed significant negative correlations with baseline OSA severity. Active treatment of OSA produced SHBG elevation and TSH reduction (P< or =0.03). Both groups showed an increase in aldosterone (P<0.001) and IGF-1 (P< or =0.03), associated with a large improvement in subjective quality of life scoring. CONCLUSIONS: These findings demonstrate significant changes in endocrine axes not previously reported in a placebo-controlled trial. OSA is a recognized reversible cause of testosterone reduction; SHBG suppression correlating to baseline OSA severity supports a diagnosis of secondary hypogonadism. Significant rises in aldosterone and IGF-1 on treatment coincide with increased physical activity and an improved quality of life score. |
| first_indexed | 2024-03-06T22:31:29Z |
| format | Journal article |
| id | oxford-uuid:58708ec8-8550-406c-bc1b-2be571bb3a1c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:31:29Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:58708ec8-8550-406c-bc1b-2be571bb3a1c2022-03-26T17:03:20ZEndocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58708ec8-8550-406c-bc1b-2be571bb3a1cEnglishSymplectic Elements at Oxford2003Meston, NDavies, RMullins, RJenkinson, CWass, JStradling, JROBJECTIVE: Obstructive sleep apnoea (OSA) is a relatively common condition producing disabling somnolence and profound physiological responses to hypoxaemic episodes during sleep, including significant oscillations in blood pressure. This study aimed to provide controlled data on the interaction between OSA and endocrine axes to establish whether overrepresentation of pathology such as hypertension and hypogonadism in OSA subjects might have an endocrine basis. DESIGN, SETTING AND SUBJECTS: Parallel randomized sham placebo controlled 1-month trial of nasal continuous positive airway pressure (nCPAP) in 101 male subjects with OSA presenting to a respiratory sleep clinic. METHODS: Analysis of gonadotrophins, testosterone, sex hormone binding protein (SHBG), prolactin, cortisol, thyroid stimulating hormone (TSH), free thyroxine (free T4), insulin-like growth factor-1 (IGF-1), renin and aldosterone were performed at baseline and after 1 month's active or placebo nCPAP intervention. Quality of life questionnaire scoring was also recorded over the same time period. RESULTS: Testosterone and SHBG showed significant negative correlations with baseline OSA severity. Active treatment of OSA produced SHBG elevation and TSH reduction (P< or =0.03). Both groups showed an increase in aldosterone (P<0.001) and IGF-1 (P< or =0.03), associated with a large improvement in subjective quality of life scoring. CONCLUSIONS: These findings demonstrate significant changes in endocrine axes not previously reported in a placebo-controlled trial. OSA is a recognized reversible cause of testosterone reduction; SHBG suppression correlating to baseline OSA severity supports a diagnosis of secondary hypogonadism. Significant rises in aldosterone and IGF-1 on treatment coincide with increased physical activity and an improved quality of life score. |
| spellingShingle | Meston, N Davies, R Mullins, R Jenkinson, C Wass, J Stradling, JR Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title | Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title_full | Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title_fullStr | Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title_full_unstemmed | Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title_short | Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea. |
| title_sort | endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea |
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