Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation

Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation

Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is unknown. We show that active phosphorylated ERK1/2 directly bi...

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Príomhchruthaitheoirí: Chatzifrangkeskou, M, Yadin, D, Marais, T, Chardonnet, S, Cohen-Tannoudji, M, Mougenot, N, Schmitt, A, Crasto, S, Di Pasquale, E, Macquart, C, Tanguy, Y, Jebeniani, I, Pucéat, M, Morales Rodriguez, B, Goldmann, W, Dal Ferro, M, Biferi, M, Knaus, P, Bonne, G, Worman, H, Muchir, A
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Oxford University Press 2018

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