Endothelial-specific Cre mouse models: Is your Cre CREdibile?
The field of vascular biology has gained enormous insight from the use of Cre and inducible Cre mouse models to temporally and spatially manipulate gene expression within the endothelium. Models are available to constitutively or inducibly modulate gene expression in all or a specified subset of end...
| Main Authors: | , , |
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| Format: | Journal article |
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American Heart Association
2018
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| _version_ | 1797069968347496448 |
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| author | Payne, S De Val, S Neal, A |
| author_facet | Payne, S De Val, S Neal, A |
| author_sort | Payne, S |
| collection | OXFORD |
| description | The field of vascular biology has gained enormous insight from the use of Cre and inducible Cre mouse models to temporally and spatially manipulate gene expression within the endothelium. Models are available to constitutively or inducibly modulate gene expression in all or a specified subset of endothelial cells. However, caution should be applied to both the selection of allele and the analysis of resultant phenotype: many similarly named Cre models have divergent activity patterns while ectopic or inconsistent Cre or inducible Cre expression can dramatically affect results. In an effort to disambiguate previous data and to provide a resource to aid appropriate experimental design, here we summarize what is known about Cre recombinase activity in the most widely used endothelial-specific Cre and Cre/ERT2 mouse models. |
| first_indexed | 2024-03-06T22:32:14Z |
| format | Journal article |
| id | oxford-uuid:58a9273a-cb76-4d9e-8bb1-361992fbd0e7 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:32:14Z |
| publishDate | 2018 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:58a9273a-cb76-4d9e-8bb1-361992fbd0e72022-03-26T17:04:54ZEndothelial-specific Cre mouse models: Is your Cre CREdibile?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58a9273a-cb76-4d9e-8bb1-361992fbd0e7Symplectic Elements at OxfordAmerican Heart Association2018Payne, SDe Val, SNeal, AThe field of vascular biology has gained enormous insight from the use of Cre and inducible Cre mouse models to temporally and spatially manipulate gene expression within the endothelium. Models are available to constitutively or inducibly modulate gene expression in all or a specified subset of endothelial cells. However, caution should be applied to both the selection of allele and the analysis of resultant phenotype: many similarly named Cre models have divergent activity patterns while ectopic or inconsistent Cre or inducible Cre expression can dramatically affect results. In an effort to disambiguate previous data and to provide a resource to aid appropriate experimental design, here we summarize what is known about Cre recombinase activity in the most widely used endothelial-specific Cre and Cre/ERT2 mouse models. |
| spellingShingle | Payne, S De Val, S Neal, A Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title | Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title_full | Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title_fullStr | Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title_full_unstemmed | Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title_short | Endothelial-specific Cre mouse models: Is your Cre CREdibile? |
| title_sort | endothelial specific cre mouse models is your cre credibile |
| work_keys_str_mv | AT paynes endothelialspecificcremousemodelsisyourcrecredibile AT devals endothelialspecificcremousemodelsisyourcrecredibile AT neala endothelialspecificcremousemodelsisyourcrecredibile |