Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence
Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperrea...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2014
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| _version_ | 1797069971176554496 |
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| author | Pike, K Davis, SA Collins, SA Lucas, J Inskip, H Wilson, S Thomas, E Wain, H Keskiväli-Bond, P Cooper, C Godfrey, K Torrens, C Roberts, G Holloway, J |
| author_facet | Pike, K Davis, SA Collins, SA Lucas, J Inskip, H Wilson, S Thomas, E Wain, H Keskiväli-Bond, P Cooper, C Godfrey, K Torrens, C Roberts, G Holloway, J |
| author_sort | Pike, K |
| collection | OXFORD |
| description | Chronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11–19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans. |
| first_indexed | 2024-03-06T22:32:17Z |
| format | Journal article |
| id | oxford-uuid:58ad6d1d-0385-4812-a8a2-dbc011ee5102 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:32:17Z |
| publishDate | 2014 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:58ad6d1d-0385-4812-a8a2-dbc011ee51022022-03-26T17:05:00ZPrenatal development is linked to bronchial reactivity: epidemiological and animal model evidenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58ad6d1d-0385-4812-a8a2-dbc011ee5102EnglishSymplectic Elements at OxfordSpringer Nature2014Pike, KDavis, SACollins, SALucas, JInskip, HWilson, SThomas, EWain, HKeskiväli-Bond, PCooper, CGodfrey, KTorrens, CRoberts, GHolloway, JChronic cardiorespiratory disease is associated with low birthweight suggesting the importance of the developmental environment. Prenatal factors affecting fetal growth are believed important, but the underlying mechanisms are unknown. The influence of developmental programming on bronchial hyperreactivity is investigated in an animal model and evidence for comparable associations is sought in humans. Pregnant Wistar rats were fed either control or protein-restricted diets throughout pregnancy. Bronchoconstrictor responses were recorded from offspring bronchial segments. Morphometric analysis of paraffin-embedded lung sections was conducted. In a human mother-child cohort ultrasound measurements of fetal growth were related to bronchial hyperreactivity, measured at age six years using methacholine. Protein-restricted rats' offspring demonstrated greater bronchoconstriction than controls. Airway structure was not altered. Children with lesser abdominal circumference growth during 11–19 weeks' gestation had greater bronchial hyperreactivity than those with more rapid abdominal growth. Imbalanced maternal nutrition during pregnancy results in offspring bronchial hyperreactivity. Prenatal environmental influences might play a comparable role in humans. |
| spellingShingle | Pike, K Davis, SA Collins, SA Lucas, J Inskip, H Wilson, S Thomas, E Wain, H Keskiväli-Bond, P Cooper, C Godfrey, K Torrens, C Roberts, G Holloway, J Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title | Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title_full | Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title_fullStr | Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title_full_unstemmed | Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title_short | Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence |
| title_sort | prenatal development is linked to bronchial reactivity epidemiological and animal model evidence |
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