Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria.
The mechanisms of death and neurologic sequelae in African children with cerebral malaria are undetermined. Because pathologic features are confined to the cerebral vasculature, perturbations in cerebral hemodynamics may be responsible. We compared the transcranial Doppler findings in 50 children wi...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1996
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| _version_ | 1797069981286924288 |
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| author | Newton, C Marsh, K Peshu, N Kirkham, F |
| author_facet | Newton, C Marsh, K Peshu, N Kirkham, F |
| author_sort | Newton, C |
| collection | OXFORD |
| description | The mechanisms of death and neurologic sequelae in African children with cerebral malaria are undetermined. Because pathologic features are confined to the cerebral vasculature, perturbations in cerebral hemodynamics may be responsible. We compared the transcranial Doppler findings in 50 children with cerebral malaria with those of 115 conscious Kenyan children. In addition, 10 children with cerebral malaria were studied during intracranial pressure monitoring and nine children were studied during the agonal stages. In the children with cerebral malaria, cerebral blood flow velocity was increased in 30%, usually associated with seizures. Of the 11 children who developed neurologic sequelae, six had sonographic abnormalities associated with lateralizing deficits, including four children with hemiparesis (in two children the contralateral middle cerebral artery could not be insonated and two had transient increases in blood flow velocity associated with seizures). In the children with severe intracranial hypertension, there was a significant linear relationship between the cerebral perfusion pressure and blood flow velocity, suggesting that autoregulation was impaired. Sonographic features of progressive intracranial hypertension, were observed in three children with cerebral malaria who died. Perturbations of cerebral hemodynamics are associated with a poor outcome in Kenyan children with cerebral malaria. |
| first_indexed | 2024-03-06T22:32:26Z |
| format | Journal article |
| id | oxford-uuid:58b7d975-97e2-481c-ac96-67f1cac1e770 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:32:26Z |
| publishDate | 1996 |
| record_format | dspace |
| spelling | oxford-uuid:58b7d975-97e2-481c-ac96-67f1cac1e7702022-03-26T17:05:21ZPerturbations of cerebral hemodynamics in Kenyans with cerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58b7d975-97e2-481c-ac96-67f1cac1e770EnglishSymplectic Elements at Oxford1996Newton, CMarsh, KPeshu, NKirkham, FThe mechanisms of death and neurologic sequelae in African children with cerebral malaria are undetermined. Because pathologic features are confined to the cerebral vasculature, perturbations in cerebral hemodynamics may be responsible. We compared the transcranial Doppler findings in 50 children with cerebral malaria with those of 115 conscious Kenyan children. In addition, 10 children with cerebral malaria were studied during intracranial pressure monitoring and nine children were studied during the agonal stages. In the children with cerebral malaria, cerebral blood flow velocity was increased in 30%, usually associated with seizures. Of the 11 children who developed neurologic sequelae, six had sonographic abnormalities associated with lateralizing deficits, including four children with hemiparesis (in two children the contralateral middle cerebral artery could not be insonated and two had transient increases in blood flow velocity associated with seizures). In the children with severe intracranial hypertension, there was a significant linear relationship between the cerebral perfusion pressure and blood flow velocity, suggesting that autoregulation was impaired. Sonographic features of progressive intracranial hypertension, were observed in three children with cerebral malaria who died. Perturbations of cerebral hemodynamics are associated with a poor outcome in Kenyan children with cerebral malaria. |
| spellingShingle | Newton, C Marsh, K Peshu, N Kirkham, F Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title | Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title_full | Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title_fullStr | Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title_full_unstemmed | Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title_short | Perturbations of cerebral hemodynamics in Kenyans with cerebral malaria. |
| title_sort | perturbations of cerebral hemodynamics in kenyans with cerebral malaria |
| work_keys_str_mv | AT newtonc perturbationsofcerebralhemodynamicsinkenyanswithcerebralmalaria AT marshk perturbationsofcerebralhemodynamicsinkenyanswithcerebralmalaria AT peshun perturbationsofcerebralhemodynamicsinkenyanswithcerebralmalaria AT kirkhamf perturbationsofcerebralhemodynamicsinkenyanswithcerebralmalaria |