Conformational studies of oligosaccharides and glycopeptides: complementarity of NMR, X-ray crystallography, and molecular modelling.

The combination of experimental and theoretical techniques gives considerable insight into oligosaccharide conformation. Through this, it became relatively straightforward to characterize the conformational properties of individual glycosidic linkages. Different types of linkages show different type...

ver descrição completa

Detalhes bibliográficos
Principais autores: Wormald, M, Petrescu, A, Pao, Y, Glithero, A, Elliott, T, Dwek, R
Formato: Journal article
Idioma:English
Publicado em: 2002
Descrição
Resumo:The combination of experimental and theoretical techniques gives considerable insight into oligosaccharide conformation. Through this, it became relatively straightforward to characterize the conformational properties of individual glycosidic linkages. Different types of linkages show different types of conformational behavior, one or more conformers, and different degrees of flexibility. A single type of linkage can show different behavior in different environments, the conformational freedom being further reduced by the surrounding residues.