Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women
Objectives: To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods: In a prospective cohort study 490 532 women aged 50-69 yrs who were recruited in the UK in 1996-2001 were followed over 2.9 yrs for incident primary hi...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
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2007
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| _version_ | 1797070035208896512 |
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| author | Liu, B Balkwill, A Banks, E Cooper, C Green, J Beral, V Collaborators, MWS |
| author_facet | Liu, B Balkwill, A Banks, E Cooper, C Green, J Beral, V Collaborators, MWS |
| author_sort | Liu, B |
| collection | OXFORD |
| description | Objectives: To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods: In a prospective cohort study 490 532 women aged 50-69 yrs who were recruited in the UK in 1996-2001 were followed over 2.9 yrs for incident primary hip and knee replacements. Results: Height, weight and BMI were all associated with the risk of hip and knee replacement. Comparing the tallest group (≥170 cm) with the shortest (<155 cm) the relative risks were 1.90 (95%CI 1.55-2.32) for hip replacement and 1.55 (95%CI 1.19-2.00) for knee replacement. Comparing the heaviest group (≥75 kg) with the lightest (<60 kg) the relative risks of hip and knee replacement were 2.37 (95%CI 2.04-2.75) and 9.71 (95%CI 7.39-12.77), respectively. Comparing obese women (BMI<30 kg/m2) to women with a BMI<22.5 kg/m2, the relative risks for hip and knee replacement were 2.47 (95%CI 2.11-2.89) and 10.51 (95%CI 7.85-14.08), respectively. These effects did not vary according to age, education, alcohol and tobacco consumption, or with use of hormonal therapies. Currently, an estimated 27% of hip replacements and 69% of knee replacements in middle-aged women in the UK are attributable to obesity. Conclusion: In middle-aged women, the risk of having a hip or knee replacement increases with both increasing height and increasing BMI. From a clinical perspective, relatively small increases in average BMI among middle-aged women are likely to have a substantial impact on the already increasing rates of joint replacement in the UK. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. |
| first_indexed | 2024-03-06T22:33:15Z |
| format | Journal article |
| id | oxford-uuid:58f8d49d-4e13-4afe-9384-9dcfa1b6312f |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:33:15Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:58f8d49d-4e13-4afe-9384-9dcfa1b6312f2022-03-26T17:07:00ZRelationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged womenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:58f8d49d-4e13-4afe-9384-9dcfa1b6312fSymplectic Elements at Oxford2007Liu, BBalkwill, ABanks, ECooper, CGreen, JBeral, VCollaborators, MWSObjectives: To examine the effect of height, weight and body mass index (BMI) on the risk of hip and knee replacement in middle-aged women. Methods: In a prospective cohort study 490 532 women aged 50-69 yrs who were recruited in the UK in 1996-2001 were followed over 2.9 yrs for incident primary hip and knee replacements. Results: Height, weight and BMI were all associated with the risk of hip and knee replacement. Comparing the tallest group (≥170 cm) with the shortest (<155 cm) the relative risks were 1.90 (95%CI 1.55-2.32) for hip replacement and 1.55 (95%CI 1.19-2.00) for knee replacement. Comparing the heaviest group (≥75 kg) with the lightest (<60 kg) the relative risks of hip and knee replacement were 2.37 (95%CI 2.04-2.75) and 9.71 (95%CI 7.39-12.77), respectively. Comparing obese women (BMI<30 kg/m2) to women with a BMI<22.5 kg/m2, the relative risks for hip and knee replacement were 2.47 (95%CI 2.11-2.89) and 10.51 (95%CI 7.85-14.08), respectively. These effects did not vary according to age, education, alcohol and tobacco consumption, or with use of hormonal therapies. Currently, an estimated 27% of hip replacements and 69% of knee replacements in middle-aged women in the UK are attributable to obesity. Conclusion: In middle-aged women, the risk of having a hip or knee replacement increases with both increasing height and increasing BMI. From a clinical perspective, relatively small increases in average BMI among middle-aged women are likely to have a substantial impact on the already increasing rates of joint replacement in the UK. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. |
| spellingShingle | Liu, B Balkwill, A Banks, E Cooper, C Green, J Beral, V Collaborators, MWS Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title | Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title_full | Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title_fullStr | Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title_full_unstemmed | Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title_short | Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women |
| title_sort | relationship of height weight and body mass index to the risk of hip and knee replacements in middle aged women |
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