Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism

To explore the functions of RUNX3 single nucleotide polymorphisms (SNPs) associated with ankylosing spondylitis (AS).Individual SNP associations were evaluated in 4230 UK cases. Their effects on transcription factor (TF) binding, transcription regulation, chromatin modifications, gene expression and...

Descripció completa

Dades bibliogràfiques
Autors principals:	Vecellio, M, Cortes, A, Roberts, A, Ellis, J, Cohen, C, Knight, J, Brown, M, Bowness, P, Wordsworth, B
Format:	Journal article
Idioma:	English
Publicat:	BMJ Publishing Group 2018

Ítems similars

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
per: Vecellio, M, et al.
Publicat: (2014)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
per: Vecellio, M, et al.
Publicat: (2021)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
per: Vecellio, M, et al.
Publicat: (2015)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
per: Vecellio, M, et al.
Publicat: (2019)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
per: Cohen, CJ, et al.
Publicat: (2022)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
per: Vecellio, M, et al.
Publicat: (2016)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
per: B. Paul Wordsworth, et al.
Publicat: (2021-03-01)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
per: Roberts, A, et al.
Publicat: (2017)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
per: Roberts, A, et al.
Publicat: (2014)

Perspectives on the genetic associations of ankylosing spondylitis
per: Wordsworth, BP, et al.
Publicat: (2021)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
per: Vecellio, ML, et al.
Publicat: (2016)

The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis
per: Watts, L, et al.
Publicat: (2018)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
per: Roberts, AR, et al.
Publicat: (2016)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
per: Wordsworth, B, et al.
Publicat: (2017)

Interleukin 10 polymorphisms in ankylosing spondylitis.
per: Goedecke, V, et al.
Publicat: (2003)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
per: Connor Davidson, et al.
Publicat: (2023-01-01)

The association of a common functional polymorphism in the tumour necrosis factor receptor 1 gene (TNFRSF1A) and disease severity in ankylosing spondylitis
per: Watts, L, et al.
Publicat: (2016)

Genetics of ankylosing spondylitis.
per: Brown, M, et al.
Publicat: (2002)

ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations
per: Roberts, A, et al.
Publicat: (2017)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
per: Roberts, AR, et al.
Publicat: (2016)

Genetic susceptibility to ankylosing spondylitis.
per: Sims, A, et al.
Publicat: (2004)

The immunology of Ankylosing Spondylitis
per: Bowness, P
Publicat: (2011)

Secretor status and ankylosing spondylitis.
per: Pal, A, et al.
Publicat: (1998)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
per: Cohen, C, et al.
Publicat: (2013)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
per: Appleton, LH, et al.
Publicat: (2016)

Susceptibility to ankylosing spondylitis.
per: Carter, N, et al.
Publicat: (2000)

The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
per: Brown, M, et al.
Publicat: (1998)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
per: Timms, A, et al.
Publicat: (2003)

Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis.
per: Milicic, A, et al.
Publicat: (2000)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
per: Holden, W, et al.
Publicat: (2003)

TNFR1 and ANKYLOSING SPONDYLITIS
per: Karaderi, T, et al.
Publicat: (2010)

The X-chromosome and susceptibility to ankylosing spondylitis.
per: Hoyle, E, et al.
Publicat: (2000)

Interleukin-1 and susceptibility to ankylosing spondylitis
per: Edwards, S, et al.
Publicat: (2001)

TRANSFORMING GROWTH FACTOR BETA-1 GENE POLYMORPHISMS AND ANKYLOSING SPONDYLITIS
per: Jaakkola, E, et al.
Publicat: (2003)

Clinical features of ankylosing spondylitis in the UK
per: Farrar, C, et al.
Publicat: (2008)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
per: Bowness, P
Publicat: (2012)

Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
per: Brown, M, et al.
Publicat: (1998)

CANDIDATE GENES FOR ANKYLOSING SPONDYLITIS
per: Pointon, J, et al.
Publicat: (2009)

Investigation of the role of ANKH in ankylosing spondylitis.
per: Timms, A, et al.
Publicat: (2003)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
per: Wordsworth, B, et al.
Publicat: (1984)