Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism

To explore the functions of RUNX3 single nucleotide polymorphisms (SNPs) associated with ankylosing spondylitis (AS).Individual SNP associations were evaluated in 4230 UK cases. Their effects on transcription factor (TF) binding, transcription regulation, chromatin modifications, gene expression and...

书目详细资料
Main Authors:	Vecellio, M, Cortes, A, Roberts, A, Ellis, J, Cohen, C, Knight, J, Brown, M, Bowness, P, Wordsworth, B
格式:	Journal article
语言:	English
出版:	BMJ Publishing Group 2018

相似书籍

FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
由: Vecellio, M, et al.
出版: (2014)

Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
由: Vecellio, M, et al.
出版: (2021)

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
由: Vecellio, M, et al.
出版: (2015)

RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
由: Vecellio, M, et al.
出版: (2019)

Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
由: Cohen, CJ, et al.
出版: (2022)

Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent RUNX3 single nucleotide polymorphisms that show strong functional effect in different cell types
由: Vecellio, M, et al.
出版: (2016)

Perspectives on the Genetic Associations of Ankylosing Spondylitis
由: B. Paul Wordsworth, et al.
出版: (2021-03-01)

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis
由: Roberts, A, et al.
出版: (2017)

ANKYLOSING SPONDYLITIS-ASSOCIATED SNPS AT THE IL23R-IL12RB2 INTERGENIC REGION ARE FUNCTIONALLY IMPORTANT
由: Roberts, A, et al.
出版: (2014)

Perspectives on the genetic associations of ankylosing spondylitis
由: Wordsworth, BP, et al.
出版: (2021)

OP0299 Susceptibility to ankylosing spondylitis is influenced independently by two closely adjacent Runx3 Snps, that show strong functional effect in different cell types
由: Vecellio, ML, et al.
出版: (2016)

The severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics are not influenced by the tumour necrosis factor receptor polymorphism incriminated in multiple sclerosis
由: Watts, L, et al.
出版: (2018)

An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation
由: Roberts, AR, et al.
出版: (2016)

Reply to Reeves et al.: No evidence for rare ERAP1 haplotypes and haplotype combinations in ankylosing spondylitis
由: Wordsworth, B, et al.
出版: (2017)

Interleukin 10 polymorphisms in ankylosing spondylitis.
由: Goedecke, V, et al.
出版: (2003)

Chromosome conformation capture approaches to investigate 3D genome architecture in Ankylosing Spondylitis
由: Connor Davidson, et al.
出版: (2023-01-01)

The association of a common functional polymorphism in the tumour necrosis factor receptor 1 gene (TNFRSF1A) and disease severity in ankylosing spondylitis
由: Watts, L, et al.
出版: (2016)

Genetics of ankylosing spondylitis.
由: Brown, M, et al.
出版: (2002)

ERAP1 association with ankylosing spondylitis is attributable to common genotypes rather than rare haplotype combinations
由: Roberts, A, et al.
出版: (2017)

OP0231 Differential transcription factor binding could explain the genetic association of ankylosing spondylitis with polymorphisms in the IL23R-IL12RB2 intergenic region
由: Roberts, AR, et al.
出版: (2016)

Genetic susceptibility to ankylosing spondylitis.
由: Sims, A, et al.
出版: (2004)

The immunology of Ankylosing Spondylitis
由: Bowness, P
出版: (2011)

Secretor status and ankylosing spondylitis.
由: Pal, A, et al.
出版: (1998)

EPIGENETIC REGULATION OF THE IL-23R LOCUS IN ANKYLOSING SPONDYLITIS
由: Cohen, C, et al.
出版: (2013)

THU0364 Rare ERAP1 allotype combinations do not explain the ERAP1 association with ankylosing spondylitis
由: Appleton, LH, et al.
出版: (2016)

Susceptibility to ankylosing spondylitis.
由: Carter, N, et al.
出版: (2000)

The role of germline polymorphisms in the T-cell receptor in susceptibility to ankylosing spondylitis.
由: Brown, M, et al.
出版: (1998)

THE ROLE OF ANKH IN ANKYLOSING SPONDYLITIS
由: Timms, A, et al.
出版: (2003)

Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis.
由: Milicic, A, et al.
出版: (2000)

MRI CHANGES IN THE CERVICAL SPINE IN PATIENTS WITH ANKYLOSING SPONDYLITIS
由: Holden, W, et al.
出版: (2003)

TNFR1 and ANKYLOSING SPONDYLITIS
由: Karaderi, T, et al.
出版: (2010)

The X-chromosome and susceptibility to ankylosing spondylitis.
由: Hoyle, E, et al.
出版: (2000)

Interleukin-1 and susceptibility to ankylosing spondylitis
由: Edwards, S, et al.
出版: (2001)

TRANSFORMING GROWTH FACTOR BETA-1 GENE POLYMORPHISMS AND ANKYLOSING SPONDYLITIS
由: Jaakkola, E, et al.
出版: (2003)

Clinical features of ankylosing spondylitis in the UK
由: Farrar, C, et al.
出版: (2008)

OVERVIEW OF ANKYLOSING SPONDYLITIS GENETICS AND PATHOGENESIS
由: Bowness, P
出版: (2012)

Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis.
由: Brown, M, et al.
出版: (1998)

CANDIDATE GENES FOR ANKYLOSING SPONDYLITIS
由: Pointon, J, et al.
出版: (2009)

Investigation of the role of ANKH in ankylosing spondylitis.
由: Timms, A, et al.
出版: (2003)

ANKYLOSING-SPONDYLITIS AND FUNCTIONAL ABILITY
由: Wordsworth, B, et al.
出版: (1984)