Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.

Orbitofrontal cortex (OFC) is widely held to be critical for flexibility in decision-making when established choice values change. OFC's role in such decision making was investigated in macaques performing dynamically changing three-armed bandit tasks. After selective OFC lesions, animals were...

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Bibliografische gegevens
Hoofdauteurs: Walton, M, Behrens, T, Buckley, M, Rudebeck, P, Rushworth, M
Formaat: Journal article
Taal:English
Gepubliceerd in: 2010
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author Walton, M
Behrens, T
Buckley, M
Rudebeck, P
Rushworth, M
author_facet Walton, M
Behrens, T
Buckley, M
Rudebeck, P
Rushworth, M
author_sort Walton, M
collection OXFORD
description Orbitofrontal cortex (OFC) is widely held to be critical for flexibility in decision-making when established choice values change. OFC's role in such decision making was investigated in macaques performing dynamically changing three-armed bandit tasks. After selective OFC lesions, animals were impaired at discovering the identity of the highest value stimulus following reversals. However, this was not caused either by diminished behavioral flexibility or by insensitivity to reinforcement changes, but instead by paradoxical increases in switching between all stimuli. This pattern of choice behavior could be explained by a causal role for OFC in appropriate contingent learning, the process by which causal responsibility for a particular reward is assigned to a particular choice. After OFC lesions, animals' choice behavior no longer reflected the history of precise conjoint relationships between particular choices and particular rewards. Nonetheless, OFC-lesioned animals could still approximate choice-outcome associations using a recency-weighted history of choices and rewards.
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spelling oxford-uuid:592d550f-c5d9-4259-a4eb-a3f9c03ba70c2022-03-26T17:08:15ZSeparable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:592d550f-c5d9-4259-a4eb-a3f9c03ba70cEnglishSymplectic Elements at Oxford2010Walton, MBehrens, TBuckley, MRudebeck, PRushworth, MOrbitofrontal cortex (OFC) is widely held to be critical for flexibility in decision-making when established choice values change. OFC's role in such decision making was investigated in macaques performing dynamically changing three-armed bandit tasks. After selective OFC lesions, animals were impaired at discovering the identity of the highest value stimulus following reversals. However, this was not caused either by diminished behavioral flexibility or by insensitivity to reinforcement changes, but instead by paradoxical increases in switching between all stimuli. This pattern of choice behavior could be explained by a causal role for OFC in appropriate contingent learning, the process by which causal responsibility for a particular reward is assigned to a particular choice. After OFC lesions, animals' choice behavior no longer reflected the history of precise conjoint relationships between particular choices and particular rewards. Nonetheless, OFC-lesioned animals could still approximate choice-outcome associations using a recency-weighted history of choices and rewards.
spellingShingle Walton, M
Behrens, T
Buckley, M
Rudebeck, P
Rushworth, M
Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title_full Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title_fullStr Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title_full_unstemmed Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title_short Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning.
title_sort separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning
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AT rudebeckp separablelearningsystemsinthemacaquebrainandtheroleoforbitofrontalcortexincontingentlearning
AT rushworthm separablelearningsystemsinthemacaquebrainandtheroleoforbitofrontalcortexincontingentlearning