Structure of three tandem filamin domains reveals auto-inhibition of ligand binding

Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IfFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 Å resolution structure of a three-domain fragment...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Lad, Y, Kiema, T, Jiang, P, Pentikäinen, O, Coles, C, Campbell, I, Calderwood, D, Ylänne, J
अन्य लेखक: European Molecular Biology Organization
स्वरूप: Journal article
भाषा:English
प्रकाशित: Nature Publishing Group 2007
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