Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IfFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 Å resolution structure of a three-domain fragment...
| Hoofdauteurs: | , , , , , , , |
|---|---|
| Andere auteurs: | |
| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
Nature Publishing Group
2007
|
| Onderwerpen: |