Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids
The common patatin-like phospholipase domain-containing protein 3 (PNPLA3) variant I148M predisposes to nonalcoholic liver disease but not its metabolic sequelae. We compared the handling of labeled polyunsaturated fatty acids (PUFAs) and saturated fatty acids (SFA) in vivo in humans and in cells ha...
Main Authors: | Luukkonen, PK, Nick, A, Hölttä-Vuori, M, Thiele, C, Isokuortti, E, Lallukka-Brück, S, Zhou, Y, Hakkarainen, A, Lundbom, N, Peltonen, M, Orho-Melander, M, Orešič, M, Hyötyläinen, T, Hodson, L, Ikonen, E, Yki-Järvinen, H |
---|---|
Format: | Journal article |
Language: | English |
Published: |
American Society for Clinical Investigation
2019
|
Similar Items
-
Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars
by: Luukkonen, P, et al.
Published: (2018) -
Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity
by: Mari Lahelma, et al.
Published: (2021-01-01) -
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
by: Yki-Järvinen, H, et al.
Published: (2021) -
PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL
by: Hagen Roland Witzel, et al.
Published: (2022-12-01) -
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
by: Palmer, C, et al.
Published: (2012)