Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.
Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an extended enzyme family that catalyze a wide range of oxidation reactions. The largest known sub-group employs 2-oxoglutarate as a cosubstrate and catalysis by these and closely related enzymes is proposed to proceed vi...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1826273829077385216 |
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| author | Clifton, I McDonough, M Ehrismann, D Kershaw, N Granatino, N Schofield, C |
| author_facet | Clifton, I McDonough, M Ehrismann, D Kershaw, N Granatino, N Schofield, C |
| author_sort | Clifton, I |
| collection | OXFORD |
| description | Mononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an extended enzyme family that catalyze a wide range of oxidation reactions. The largest known sub-group employs 2-oxoglutarate as a cosubstrate and catalysis by these and closely related enzymes is proposed to proceed via a ferryl intermediate coordinated to the active site via a conserved HXD/E...H motif. Crystallographic studies on the 2-oxoglutarate oxygenases and related enzymes have revealed a common double-stranded beta-helix core fold that supports the residues coordinating the iron. This fold is common to proteins of the cupin and the JmjC transcription factor families. The crystallographic studies on 2-oxoglutarate oxygenases and closely related enzymes are reviewed and compared with other metallo-enzymes/related proteins containing a double-stranded beta-helix fold. Proposals regarding the suitability of the active sites and folds of the 2-oxoglutarate oxygenases to catalyze reactions involving reactive oxidizing species are described. |
| first_indexed | 2024-03-06T22:34:10Z |
| format | Journal article |
| id | oxford-uuid:594c90c9-7b90-4c99-bf11-722964c8309e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:34:10Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:594c90c9-7b90-4c99-bf11-722964c8309e2022-03-26T17:08:57ZStructural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:594c90c9-7b90-4c99-bf11-722964c8309eEnglishSymplectic Elements at Oxford2006Clifton, IMcDonough, MEhrismann, DKershaw, NGranatino, NSchofield, CMononuclear non-heme ferrous iron dependent oxygenases and oxidases constitute an extended enzyme family that catalyze a wide range of oxidation reactions. The largest known sub-group employs 2-oxoglutarate as a cosubstrate and catalysis by these and closely related enzymes is proposed to proceed via a ferryl intermediate coordinated to the active site via a conserved HXD/E...H motif. Crystallographic studies on the 2-oxoglutarate oxygenases and related enzymes have revealed a common double-stranded beta-helix core fold that supports the residues coordinating the iron. This fold is common to proteins of the cupin and the JmjC transcription factor families. The crystallographic studies on 2-oxoglutarate oxygenases and closely related enzymes are reviewed and compared with other metallo-enzymes/related proteins containing a double-stranded beta-helix fold. Proposals regarding the suitability of the active sites and folds of the 2-oxoglutarate oxygenases to catalyze reactions involving reactive oxidizing species are described. |
| spellingShingle | Clifton, I McDonough, M Ehrismann, D Kershaw, N Granatino, N Schofield, C Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title | Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title_full | Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title_fullStr | Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title_full_unstemmed | Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title_short | Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. |
| title_sort | structural studies on 2 oxoglutarate oxygenases and related double stranded beta helix fold proteins |
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