Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease.
Using dye staining and a magnifying colonoscope, small lesions in the rectum of patients with Crohn's disease (which had otherwise appeared normal on sigmoidoscopy) can be detected. Subpopulations of macrophages and lymphocytes in the abnormal and adjacent normal areas of the rectum were studie...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1988
|
| _version_ | 1826273829476892672 |
|---|---|
| author | Gionchetti, P Mahida, Y Patel, S Jewell, D |
| author_facet | Gionchetti, P Mahida, Y Patel, S Jewell, D |
| author_sort | Gionchetti, P |
| collection | OXFORD |
| description | Using dye staining and a magnifying colonoscope, small lesions in the rectum of patients with Crohn's disease (which had otherwise appeared normal on sigmoidoscopy) can be detected. Subpopulations of macrophages and lymphocytes in the abnormal and adjacent normal areas of the rectum were studied using a panel of monoclonal antibodies. There was a distinct increase in RFD9+ and 3G8+ macrophages in the abnormal areas compared with the normal. The CD4:CD8 ratio of lymphocytes in the two areas remained unchanged. |
| first_indexed | 2024-03-06T22:34:10Z |
| format | Journal article |
| id | oxford-uuid:594cc8fb-5421-4308-9d33-312117157c3f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:34:10Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:594cc8fb-5421-4308-9d33-312117157c3f2022-03-26T17:09:05ZMacrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:594cc8fb-5421-4308-9d33-312117157c3fEnglishSymplectic Elements at Oxford1988Gionchetti, PMahida, YPatel, SJewell, DUsing dye staining and a magnifying colonoscope, small lesions in the rectum of patients with Crohn's disease (which had otherwise appeared normal on sigmoidoscopy) can be detected. Subpopulations of macrophages and lymphocytes in the abnormal and adjacent normal areas of the rectum were studied using a panel of monoclonal antibodies. There was a distinct increase in RFD9+ and 3G8+ macrophages in the abnormal areas compared with the normal. The CD4:CD8 ratio of lymphocytes in the two areas remained unchanged. |
| spellingShingle | Gionchetti, P Mahida, Y Patel, S Jewell, D Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title | Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title_full | Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title_fullStr | Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title_full_unstemmed | Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title_short | Macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of Crohn's disease. |
| title_sort | macrophage and lymphocyte subpopulations in magnifying endoscopic lesions of crohn s disease |
| work_keys_str_mv | AT gionchettip macrophageandlymphocytesubpopulationsinmagnifyingendoscopiclesionsofcrohnsdisease AT mahiday macrophageandlymphocytesubpopulationsinmagnifyingendoscopiclesionsofcrohnsdisease AT patels macrophageandlymphocytesubpopulationsinmagnifyingendoscopiclesionsofcrohnsdisease AT jewelld macrophageandlymphocytesubpopulationsinmagnifyingendoscopiclesionsofcrohnsdisease |