Safety and efficacy of elsubrutinib or upadacitinib alone or in combination (ABBV-599) in patients with rheumatoid arthritis and inadequate response or intolerance to biological therapies: a multicentre, double-blind, randomised, controlled, phase 2 trial

Background ABBV-599 is a novel fixed-dose combination of the Bruton's tyrosine kinase (BTK) inhibitor elsubrutinib and the Janus kinase (JAK) inhibitor upadacitinib under investigation for the treatment of autoimmune diseases. We aimed to determine whether ABBV-599 could increase the treatment...

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Main Authors: Fleischmann, R, Friedman, A, Drescher, E, Singhal, A, Cortes-Maisonet, G, Doan, T, Lu, W, Wang, Z, Nader, A, Housley, W, Cohen, S, Taylor, PC, Blanco, R
格式: Journal article
语言:English
出版: Elsevier 2022