Distinct factors control histone variant H3.3 localization at specific genomic regions.

Distinct factors control histone variant H3.3 localization at specific genomic regions.

The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc-finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem cells and neuronal precursor cells. Genome-wide p...

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Bibliographic Details
Main Authors: Goldberg, A, Banaszynski, L, Noh, K, Lewis, P, Elsaesser, S, Stadler, S, Dewell, S, Law, M, Guo, X, Li, X, Wen, D, Chapgier, A, Dekelver, R, Miller, J, Lee, Y, Boydston, E, Holmes, M, Gregory, P, Greally, J, Rafii, S, Yang, C, Scambler, P, Garrick, D, Gibbons, R, Higgs, D, Cristea, I, Urnov, F, Zheng, D, Allis, C
Format: Journal article
Language:English
Published: Elsevier 2010

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