Polysaccharide-specific B cell responses to vaccination in humans.
The introduction of vaccines containing the capsular polysaccharides of N. meningitidis, S. pneumonia, and H. influenzae type b has driven a significant reduction in cases of disease caused by these bacteria. The polysaccharide-specific antibody responses following vaccination are well characterized...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Landes Bioscience
2014
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| _version_ | 1826273918842830848 |
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| author | Mitchell, R Kelly, D Pollard, A Trück, J |
| author_facet | Mitchell, R Kelly, D Pollard, A Trück, J |
| author_sort | Mitchell, R |
| collection | OXFORD |
| description | The introduction of vaccines containing the capsular polysaccharides of N. meningitidis, S. pneumonia, and H. influenzae type b has driven a significant reduction in cases of disease caused by these bacteria. The polysaccharide-specific antibody responses following vaccination are well characterized, however less is known about the B cells underlying this response. Here, we summarize the plasma cell (PC) and memory B cell (BMEM) responses following plain polysaccharide and protein-polysaccharide conjugate vaccination, drawing together studies covering a range of vaccines and age groups. These studies show that infant primary PC and BMEM responses to polysaccharide-conjugate vaccines are low in relation to older age groups but are significantly higher following booster doses. PC kinetics have generally been found to follow a similar pattern irrespective of vaccine type or age group, whereas divergent BMEM responses have been reported following plain polysaccharide and conjugate vaccination. A degree of correlation between early BMEM responses and maintenance of protective antibody levels has been identified in some studies, but the relationship between the 2 remains unclear. Identification of the B cell subsets involved and the mechanisms by which they are induced may provide a better understanding of the role of B cells in maintaining protective immunity through vaccination. |
| first_indexed | 2024-03-06T22:35:32Z |
| format | Journal article |
| id | oxford-uuid:59c1dbb1-d6f3-4a3b-9dd5-a0e6495dc4c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:35:32Z |
| publishDate | 2014 |
| publisher | Landes Bioscience |
| record_format | dspace |
| spelling | oxford-uuid:59c1dbb1-d6f3-4a3b-9dd5-a0e6495dc4c92022-03-26T17:11:41ZPolysaccharide-specific B cell responses to vaccination in humans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:59c1dbb1-d6f3-4a3b-9dd5-a0e6495dc4c9EnglishSymplectic Elements at OxfordLandes Bioscience2014Mitchell, RKelly, DPollard, ATrück, JThe introduction of vaccines containing the capsular polysaccharides of N. meningitidis, S. pneumonia, and H. influenzae type b has driven a significant reduction in cases of disease caused by these bacteria. The polysaccharide-specific antibody responses following vaccination are well characterized, however less is known about the B cells underlying this response. Here, we summarize the plasma cell (PC) and memory B cell (BMEM) responses following plain polysaccharide and protein-polysaccharide conjugate vaccination, drawing together studies covering a range of vaccines and age groups. These studies show that infant primary PC and BMEM responses to polysaccharide-conjugate vaccines are low in relation to older age groups but are significantly higher following booster doses. PC kinetics have generally been found to follow a similar pattern irrespective of vaccine type or age group, whereas divergent BMEM responses have been reported following plain polysaccharide and conjugate vaccination. A degree of correlation between early BMEM responses and maintenance of protective antibody levels has been identified in some studies, but the relationship between the 2 remains unclear. Identification of the B cell subsets involved and the mechanisms by which they are induced may provide a better understanding of the role of B cells in maintaining protective immunity through vaccination. |
| spellingShingle | Mitchell, R Kelly, D Pollard, A Trück, J Polysaccharide-specific B cell responses to vaccination in humans. |
| title | Polysaccharide-specific B cell responses to vaccination in humans. |
| title_full | Polysaccharide-specific B cell responses to vaccination in humans. |
| title_fullStr | Polysaccharide-specific B cell responses to vaccination in humans. |
| title_full_unstemmed | Polysaccharide-specific B cell responses to vaccination in humans. |
| title_short | Polysaccharide-specific B cell responses to vaccination in humans. |
| title_sort | polysaccharide specific b cell responses to vaccination in humans |
| work_keys_str_mv | AT mitchellr polysaccharidespecificbcellresponsestovaccinationinhumans AT kellyd polysaccharidespecificbcellresponsestovaccinationinhumans AT pollarda polysaccharidespecificbcellresponsestovaccinationinhumans AT truckj polysaccharidespecificbcellresponsestovaccinationinhumans |