The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.
Adhesion-GPCRs provide essential cell-cell and cell-matrix interactions in development, and have been implicated in inherited human diseases like Usher Syndrome and bilateral frontoparietal polymicrogyria. They are the second largest subfamily of seven-transmembrane spanning proteins in vertebrates,...
Glavni autori: | Waller-Evans, H, Promel, S, Langenhan, T, Dixon, J, Zahn, D, Colledge, W, Doran, J, Carlton, M, Davies, B, Aparicio, SA, Grosse, J, Russ, A |
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Format: | Journal article |
Jezik: | English |
Izdano: |
Public Library of Science
2010
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