B cell antigen receptor signalling in the balance of tolerance and immunity.
The quantity and quality of signals from the B cell antigen receptor (BCR) drives the positive and negative selection of B lymphocytes and establishes the balance of tolerance and immunity. Experiments using immunoglobulin transgenic mice and mutations in key BCR signalling components have given ins...
Main Authors: | Cornall, R, Goodnow, C |
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Format: | Conference item |
Published: |
1998
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