Biomarkers of inflammation predict both vascular and non-vascular mortality in older men.
AIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age...
| Главные авторы: | , , , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
2008
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| _version_ | 1826273928806400000 |
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| author | Clarke, R Emberson, J Breeze, E Casas, J Parish, S Hingorani, A Fletcher, A Collins, R Smeeth, L |
| author_facet | Clarke, R Emberson, J Breeze, E Casas, J Parish, S Hingorani, A Fletcher, A Collins, R Smeeth, L |
| author_sort | Clarke, R |
| collection | OXFORD |
| description | AIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)]. CONCLUSION: In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics. |
| first_indexed | 2024-03-06T22:35:41Z |
| format | Journal article |
| id | oxford-uuid:59d07480-4a0f-479d-b212-bbd057322509 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:35:41Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:59d07480-4a0f-479d-b212-bbd0573225092022-03-26T17:11:57ZBiomarkers of inflammation predict both vascular and non-vascular mortality in older men.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:59d07480-4a0f-479d-b212-bbd057322509EnglishSymplectic Elements at Oxford2008Clarke, REmberson, JBreeze, ECasas, JParish, SHingorani, AFletcher, ACollins, RSmeeth, LAIMS: To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men. METHODS AND RESULTS: The relevance of inflammatory biomarkers and lipids for vascular and non-vascular mortality was assessed in a prospective study of 5360 men (mean age 77 years) followed for 7 years. Vascular mortality was positively associated with log C-reactive protein (lnCRP), fibrinogen and total/HDL-C (high-density lipoprotein cholesterol), and inversely associated with albumin [age adjusted hazard ratio (HR) per 2-SD higher usual level (approximately the difference between the top and the bottom thirds of the distribution): 2.09 for lnCRP; 1.70 for fibrinogen; 0.50 for albumin and 1.45 for total/HDL-C]. The associations with the inflammatory markers were attenuated after adjustment for established risk factors, including lipids [adjusted HRs: 1.86 (lnCRP); 1.44 (fibrinogen); 0.51 (albumin)], and further attenuated (and, for fibrinogen, no longer predictive) after adjustment for each other [fully adjusted HRs: 1.60 (lnCRP); 1.01 (fibrinogen); 0.61 (albumin)]. Higher CRP and lower albumin levels were also associated with significantly raised non-vascular mortality independently of other characteristics [fully adjusted HRs: 1.62 (lnCRP); 0.65 (albumin)]. CONCLUSION: In this cohort of older men, higher CRP and lower albumin levels strongly predicted both vascular and non-vascular mortality, independently of other characteristics. |
| spellingShingle | Clarke, R Emberson, J Breeze, E Casas, J Parish, S Hingorani, A Fletcher, A Collins, R Smeeth, L Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title | Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title_full | Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title_fullStr | Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title_full_unstemmed | Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title_short | Biomarkers of inflammation predict both vascular and non-vascular mortality in older men. |
| title_sort | biomarkers of inflammation predict both vascular and non vascular mortality in older men |
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