Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias

The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. The central importance of the CaSR...

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Bibliographic Details
Main Authors:	Gorvin, C, Frost, M, Malinauskas, T, Cranston, T, Boon, H, Siebold, C, Jones, E, Hannan, F, Thakker, R
Format:	Journal article
Language:	English
Published:	Oxford University Press 2018

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