Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias
The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. The central importance of the CaSR...
Main Authors: | Gorvin, C, Frost, M, Malinauskas, T, Cranston, T, Boon, H, Siebold, C, Jones, E, Hannan, F, Thakker, R |
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Format: | Journal article |
Language: | English |
Published: |
Oxford University Press
2018
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