Synthesis and biological evaluation of phospholane and dihydrophosphole analogues of the glutamate receptor agonist AP4

The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.

Chi tiết về thư mục
Những tác giả chính: Conway, S, Miller, J, Bond, A, Clark, B, Jane, D
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2002
Miêu tả
Tóm tắt:The syntheses and preliminary pharmacological characterisation of two novel cyclic phosphinic acid-containing amino acids designed as conformationally restricted analogues of the metabotropic glutamate receptor agonist AP4 (1) are reported.