Scalable purification of viral vectors for gene therapy: An appraisal of downstream processing approaches

Scalable purification of viral vectors for gene therapy: An appraisal of downstream processing approaches

Process concerns associated with viral-vectors gene delivery currently focus on effective purification, as described by these authors from the Centre for the Advancement of Sustainable Medical Innovation and Sartorius Stedim Biotech. For research into cell-delivered gene therapy platforms to continu...

Full description

Bibliographic Details
Main Authors:	Fuerstenau-Sharp, M, Pettitt, D, Bure, K, Smith, J, Ware, J, Brindley, D
Format:	Journal article
Published:	BioProcess International 2017

Similar Items

Emerging platform bioprocesses for viral vectors and gene therapies
by: Pettitt, D, et al.
Published: (2016)

Viral vectors for gene therapy : methods and protocols /
by: Machida, Curtis A.
Published: (2003)

Gene therapy using viral vector against anxiety
by: Loo, Sze Jie
Published: (2016)

Cellular uptake study of non-viral vectors for gene therapy.
by: Teo, Zi Yong.
Published: (2012)

Technique of retinal gene therapy: delivery of viral vector into the subretinal space
by: Xue, K, et al.
Published: (2017)

Gene Therapy for Choroideremia Using an Adeno-Associated Viral (AAV) Vector.
by: Barnard, A, et al.
Published: (2014)

Bioprocess decision support tool for scalable manufacture of extracellular vesicles
by: Ng, K, et al.
Published: (2018)

Downstream processing and bioseparation : recovery and purification of biological products/
by: Hamel, Jean-Francois P., et al.
Published: (1990)

Designing downstream processes for large-scale protein purification /
by: 278284 Wheelwright, Scoh M.

Protein purification : design and scale up of downstream processing /
by: 321410 Wheelwright, Scott M.
Published: (1991)

Cell therapy commercialization: An assessment of translational barriers
by: Pettitt, D, et al.
Published: (2016)

Bioprocess decision support tool for scalable manufacture of extracellular vesicles
by: Ng, KS, et al.
Published: (2022)

Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects.
by: Pringle, I, et al.
Published: (2009)

General Overview of Viral/Non-viral Gene Therapy
by: Seymour, L
Published: (2011)

Systems for gene delivery based on combination of viral and non-viral vectors
by: Carlisle, R, et al.
Published: (2000)

UPDATE ON THE UK CF GENE THERAPY CONSORTIUM MULTIDOSE, NON-VIRAL, GENE THERAPY TRIAL
by: Alton, E, et al.
Published: (2012)

UPDATE ON THE UK CF GENE THERAPY CONSORTIUM MULTIDOSE, NON-VIRAL, GENE THERAPY TRIAL
by: Alton, E, et al.
Published: (2012)

Adenoviral vectors for gene therapy /
by: Curiel, David T., et al.
Published: (2002)

Viral vector vaccines
by: McCann, N, et al.
Published: (2022)

Biological gene delivery vehicles: beyond viral vectors.
by: Seow, Y, et al.
Published: (2009)

Non-viral gene therapy : gene design and delivery /
by: Taira, K. (Kazunari), et al.
Published: (2005)

Update on the UK CF Gene Therapy Consortium Multidoes, non-viral, gene therapy trial
by: Alton, E, et al.
Published: (2012)

High capacity viral vectors for genomic DNA transgene delivery: Applications to gene therapy and functional genomics
by: Wade-Martins, R, et al.
Published: (2004)

Episomal non-viral gene therapy vectors slow progression of atherosclerosis in a model of familial hypercholesterolemia
by: Kerr, A, et al.
Published: (2016)

Bioprocessing automation in cell therapy manufacturing: Outcomes of special interest group automation workshop
by: Ball, O, et al.
Published: (2018)

Developing combination therapy to improve viral vector cancer vaccine efficacy
by: Noblecourt, L
Published: (2023)

Bioprocess decision support tool for scalable manufacture of extracellular vesicles
by: Ng, Kelvin S., et al.
Published: (2022)

Effective gene therapy with nonintegrating lentiviral vectors.
by: Yáñez-Muñoz, R, et al.
Published: (2006)

Viral vectors for malaria vaccine development.
by: Li, S, et al.
Published: (2007)

Non-viral retinal gene therapy: A review
by: Issa, P, et al.
Published: (2012)

Non-viral retinal gene therapy: a review.
by: Charbel Issa, P, et al.
Published: (2012)

Appendix A: Legal framework on the scientific use of animals in research
by: Pettitt, D, et al.
Published: (2017)

Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium.
by: Hudde, T, et al.
Published: (1999)

Optimising the quality and effectiveness of risk: benefit appraisal methodologies utilised in randomised control trials
by: Brindley, D, et al.
Published: (2015)

Adeno-associated virus vectors for gene therapy /
by: Flotte, T. R., et al.
Published: (2005)

Viral therapy of cancer /
by: Harrington, Kevin J., 1958-, et al.
Published: (2008)

Lentiviral vector for p47phox gene therapy
by: Haenseler, W, et al.
Published: (2013)

Upstream Competition and Downstream Buyer Power.
by: Smith, H, et al.
Published: (2009)

Adeno‐associated viral vectored delivery of a monoclonal antibody gene against blood‐stage malaria
by: Bardelli, M, et al.
Published: (2019)

Products Manufactured From Human Blood and Plasma
by: Ware, J, et al.
Published: (2017)