Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

Enhanced vaccine-induced CD8+ T cell responses to malaria antigen ME-TRAP by fusion to MHC class ii invariant chain.

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4+ T cells, but enhanced CD8+ T cells responses have been reported after vaccination with vectored viral vaccines encoding a fusion of Ii to the antigen of interest. In this study we assessed whether fusion of the ma...

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Bibliographic Details
Main Authors:	Spencer, A, Cottingham, M, Jenks, J, Longley, R, Capone, S, Colloca, S, Folgori, A, Cortese, R, Nicosia, A, Bregu, M, Hill, A
Format:	Journal article
Language:	English
Published:	Public Library of Science 2014

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