Bilateral generic working memory circuit requires left-lateralized addition for verbal processing
According to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM-left; spatial WM-right) has...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Oxford University Press
2008
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| Subjects: |
| _version_ | 1797070369716174848 |
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| author | Ray, M Mackay, C Harmer, C Crow, T |
| author_facet | Ray, M Mackay, C Harmer, C Crow, T |
| author_sort | Ray, M |
| collection | OXFORD |
| description | According to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM-left; spatial WM-right) has been challenged by the position that a common bilateral frontparietal network subserves both domains. Here, we test the hypothesis that there is a generic WM circuit that recruits additional specialized regions for verbal and spatial processing. We designed a functional magnetic resonance imaging paradigm to elicit activation in the WM circuit for verbal and spatial information using identical stimuli and applied this in 33 healthy controls. We detected left-lateralized quantitative differences in the left frontal and temporal lobe for verbal > spatial WM but no areas of activation for spatial > verbal WM. We speculate that spatial WM is analogous to a "generic" bilateral frontoparietal WM circuit we inherited from our great ape ancestors that evolved, by recruitment of additional left-lateralized frontal and temporal regions, to accommodate language. |
| first_indexed | 2024-03-06T22:37:49Z |
| format | Journal article |
| id | oxford-uuid:5a870ce7-86b5-4fb2-945c-de98e8cbfc39 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:37:49Z |
| publishDate | 2008 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:5a870ce7-86b5-4fb2-945c-de98e8cbfc392022-03-26T17:16:13ZBilateral generic working memory circuit requires left-lateralized addition for verbal processingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5a870ce7-86b5-4fb2-945c-de98e8cbfc39PsychiatryEnglishOxford University Research Archive - ValetOxford University Press2008Ray, MMackay, CHarmer, CCrow, TAccording to the Baddeley-Hitch model, phonological and visuospatial representations are separable components of working memory (WM) linked by a central executive. The traditional view that the separation reflects the relative contribution of the 2 hemispheres (verbal WM-left; spatial WM-right) has been challenged by the position that a common bilateral frontparietal network subserves both domains. Here, we test the hypothesis that there is a generic WM circuit that recruits additional specialized regions for verbal and spatial processing. We designed a functional magnetic resonance imaging paradigm to elicit activation in the WM circuit for verbal and spatial information using identical stimuli and applied this in 33 healthy controls. We detected left-lateralized quantitative differences in the left frontal and temporal lobe for verbal > spatial WM but no areas of activation for spatial > verbal WM. We speculate that spatial WM is analogous to a "generic" bilateral frontoparietal WM circuit we inherited from our great ape ancestors that evolved, by recruitment of additional left-lateralized frontal and temporal regions, to accommodate language. |
| spellingShingle | Psychiatry Ray, M Mackay, C Harmer, C Crow, T Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title_full | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title_fullStr | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title_full_unstemmed | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title_short | Bilateral generic working memory circuit requires left-lateralized addition for verbal processing |
| title_sort | bilateral generic working memory circuit requires left lateralized addition for verbal processing |
| topic | Psychiatry |
| work_keys_str_mv | AT raym bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT mackayc bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT harmerc bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing AT crowt bilateralgenericworkingmemorycircuitrequiresleftlateralizedadditionforverbalprocessing |