The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy

The role of nitric oxide synthase (nos) and the cofactor tetrahydrobiopterin (bh4) in diabetic cardiomyopathy

<p>The work presented within this thesis investigates the mechanisms which underlie the cardiovascular phenotype observed in a mouse model of type 1 diabetic cardiomyopathy. It demonstrates the protective effects of augmenting the NOS cofactor, BH4, to said cardiomyopathy, and explores the dif...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Duglan, D
Awduron Eraill:	Casadei, B
Fformat:	Traethawd Ymchwil
Cyhoeddwyd:	2016

Eitemau Tebyg

P683The role of nitric oxide synthase (NOS) and its essential cofactor tetrahydrobiopterin (BH4) in diabetic cardiomyopathy.
gan: Duglan, D, et al.
Cyhoeddwyd: (2014)

Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats.
gan: Gangula, P, et al.
Cyhoeddwyd: (2010)

Prenatal Diagnosis of Tetrahydrobiopterin (BH4) Synthase Deficiency
gan: Shintaku H., et al.
Cyhoeddwyd: (1991-02-01)

Tetrahydrobiopterin and nitric oxide synthase recouplers
gan: Channon, KM
Cyhoeddwyd: (2020)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
gan: Cai, S, et al.
Cyhoeddwyd: (2005)

Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling.
gan: Hashimoto, T, et al.
Cyhoeddwyd: (2016)

Tetrahydrobiopterin protects against hypertrophic heart disease independent of myocardial nitric oxide synthase coupling
gan: Hashimoto, T, et al.
Cyhoeddwyd: (2016)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
gan: Alp, N, et al.
Cyhoeddwyd: (2004)

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling
gan: Toru Hashimoto, et al.
Cyhoeddwyd: (2016-03-01)

The Critical Role of Tetrahydrobiopterin (BH4) Metabolism in Modulating Radiosensitivity: BH4/NOS Axis as an Angel or a Devil
gan: Yang Feng, et al.
Cyhoeddwyd: (2021-08-01)

Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling.
gan: Alkaitis, MS, et al.
Cyhoeddwyd: (2012)

Recoupling the cardiac nitric oxide synthases: Tetrahydrobiopterin synthesis and recycling
gan: Alkaitis, MS, et al.
Cyhoeddwyd: (2012)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
gan: Alp, N, et al.
Cyhoeddwyd: (2004)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
gan: Channon, K
Cyhoeddwyd: (2004)

Tetrahydrobiopterin (BH4), a cofactor for nNOS activity, restores gastric emptying in female diabetic rats: Further evidence for gender specific mechanisms in the pathogenesis of diabetic gastroparesis
gan: Gangula, P, et al.
Cyhoeddwyd: (2007)

Tetrahydrobiopterin deficiency uncouples nitric oxide synthase and causes pulmonary hypertension
gan: Khoo, J, et al.
Cyhoeddwyd: (2004)

Tetrahydrobiopterin (Bh4) deficiencies: diagnosis and treatment
gan: Mercedes Martínez-Pardo
Cyhoeddwyd: (2014-07-01)

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences
gan: Laurent Chatre, et al.
Cyhoeddwyd: (2022-09-01)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
gan: Khoo, J, et al.
Cyhoeddwyd: (2005)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
gan: Cai, S, et al.
Cyhoeddwyd: (2004)

Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor
gan: Tuany Eichwald, et al.
Cyhoeddwyd: (2023-05-01)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
gan: Bendall, J, et al.
Cyhoeddwyd: (2005)

Circulatory Estradiol Influences Gastric Emptying, Nitrergic Relaxation via Tetrahydrobiopterin (BH4, a cofactor nNOS dimerization) in a female Mouse, Model of Chronic Hypoestrogenemia
gan: Gangula, P, et al.
Cyhoeddwyd: (2012)

Circulatory Estradiol Influences Gastric Emptying, Nitrergic Relaxation via Tetrahydrobiopterin (BH4, a cofactor nNOS dimerization) in a female Mouse, Model of Chronic Hypoestrogenemia
gan: Gangula, P, et al.
Cyhoeddwyd: (2010)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
gan: Crabtree, M, et al.
Cyhoeddwyd: (2011)

Tetrahydrobiopterin Prevents Lung Ischemia/reperfusion-Induced Uncoupling of Endothelial Nitric Oxide Synthase
gan: Juni, R, et al.
Cyhoeddwyd: (2012)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
gan: Crabtree, M, et al.
Cyhoeddwyd: (2011)

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
gan: Benson, M, et al.
Cyhoeddwyd: (2013)

Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies
gan: Thomas Opladen, et al.
Cyhoeddwyd: (2020-05-01)

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin
gan: Mueller Nicolas J, et al.
Cyhoeddwyd: (2002-11-01)

Correction to: Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH4) deficiencies
gan: Thomas Opladen, et al.
Cyhoeddwyd: (2020-08-01)

Integrated redox sensor and effector functions for tetrahydrobiopterin- and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling.
gan: Crabtree, M, et al.
Cyhoeddwyd: (2013)

BH4 increases nNOS Activity and preserves left ventricular function in diabetes
gan: Carnicer Hijazo, R, et al.
Cyhoeddwyd: (2021)

The expanding roles of neuronal nitric oxide synthase (NOS1)
gan: Kundan Solanki, et al.
Cyhoeddwyd: (2022-07-01)

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells.
gan: Cai, S, et al.
Cyhoeddwyd: (2005)

Tetrahydrobiopterin (BH<sub>4</sub>) Supplementation Prevents the Cardiorenal Effects of Diabetes in Mice by Reducing Oxidative Stress, Inflammation and Fibrosis
gan: Ulises Novoa, et al.
Cyhoeddwyd: (2022-10-01)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
gan: Rinze, R, et al.
Cyhoeddwyd: (2008)

Tetrahydrobiopterin (BH4) deficiency is associated with augmented inflammation and microvascular degeneration in the retina
gan: José Carlos Rivera, et al.
Cyhoeddwyd: (2017-09-01)

Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation.
gan: Hu Peng, et al.
Cyhoeddwyd: (2015-01-01)

The % tetrahydrobiopterin (BH4) and serine 1177 phosphorylation 19 reduced in sickle transgenic mice
gan: Chen, Q, et al.
Cyhoeddwyd: (2007)