Biosynthesis of carbapenem antibiotics: new carbapenam substrates for carbapenem synthase (CarC).

A non-haem iron and 2-oxoglutarate oxygenase, CarC catalyses the highly unusual epimerisation and desaturation of a (3S,5S)-carbapenam 2 to give a (5R)-carbapenem 1. All stereoisomers of 2 were synthesised and analysed as CarC substrates. The results imply that the (3S,5S)-carbapenam is an intermedi...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: Sleeman, M, Smith, P, Kellam, B, Chhabra, SR, Bycroft, B, Schofield, C
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2004